外泌体装饰的生物隔膜可减少热量和 ROS 的传递距离，从而促进抗菌和肿瘤治疗。

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2024-10-25 DOI:10.1016/j.biomaterials.2024.122921

Yanni Li , Lin Chen , Yonghao Chen , Hongxing Shi , Sheng Yu , Adeleye Funmilayo , Chao Wu , Chunhui Wang , Yi Deng

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引用次数: 0

摘要

光热和光动力疗法是对付细菌和肿瘤细胞的有效方法。然而，从光敏剂到靶点的热量和活性氧（ROS）传递距离限制了治疗效果。为了解决这个问题，我们设计并开发了由 MXene（Ti3C2）、液态金属（LM）和来自 CT26 细胞的外泌体组成的外泌体装饰生物超结（E-bioHJ），以增强光治疗效果。工程E-bioHJ增强了抗菌和抗肿瘤治疗中的光疗效果，这归因于减少了热量和ROS的传递距离。E-bioHJ 与外泌体结合后，在 808 纳米近红外辐射下被靶向递送到肿瘤细胞的细胞质中，产生热量和 ROS，进一步诱导线粒体功能障碍和细胞凋亡/坏死。正如所设想的那样，这项研究提出了一种新方法，通过减少热量和 ROS 的传输距离来提高生物材料的抗菌和抗肿瘤功效。

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Exosome-decorated bio-heterojunctions reduce heat and ROS transfer distance for boosted antibacterial and tumor therapy

Photothermal and photodynamic therapies represent effective modalities for combatting bacteria and tumor cells. However, therapeutic outcomes are constrained by limitations related to the heat and reactive oxygen species (ROS) transfer distance from photosensitizers to targets. To address this issue, we have devised and developed exosome-decorated bio-heterojunctions (E-bioHJ) consisted of MXene (Ti₃C₂), liquid metal (LM) and exosomes sourced from CT26 cells to enhance the phototherapeutic consequences. Engineering E-bioHJ enhances phototherapeutic effect in antibacterial and anti-tumor treatment, which is ascribed to reducing transfer distance of the heat and ROS. When adorned with exosomes, E-bioHJ is targetedly delivered into the cytoplasm of tumor cells to generate amount heat and ROS under 808 nm near-infrared radiation, which further induces mitochondrial dysfunction and apoptosis/necroptosis. As envisaged, this study presents a novel tactic to enhance the antibacterial and anti-tumor efficacy of biomaterials through reducing the heat and ROS delivery travel distance.

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.