Yaolei Li, Jing Fan, Hongyu Jin, Feng Wei, Shuangcheng Ma
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We introduced a novel perspective that integrated inorganic and organic components, overcoming traditional paradigms. The review analysis highlighted unique role of elemental fingerprints in revealing the scientific connotation of TCM. Furthermore, we proposed an innovative strategy for identifying key components, which effectively addressed the limitations of traditional methods and elevated the overall evaluation standards for TCM. This strategy was supported by emerging technologies such as artificial intelligence, metallomics, and hyperspectral imaging. Looking ahead, the application prospects of the combined strategy of elemental fingerprints and key components were promising. It not only provided a solid foundation for the formulation of TCM quality control strategies but also introduced new methodologies and tools to the field of regulatory science and scientific oversight of TCM.","PeriodicalId":314,"journal":{"name":"European Journal of Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New vision for TCM quality control: elemental fingerprints and key ingredient combination strategy for identification and evaluation of TCMs\",\"authors\":\"Yaolei Li, Jing Fan, Hongyu Jin, Feng Wei, Shuangcheng Ma\",\"doi\":\"10.1016/j.ejmech.2024.117006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The quality control of Traditional Chinese Medicine (TCM) is crucial for ensuring its efficacy and safety. Traditional methods, however, have limitations in fully capturing the natural essence of TCM, thus hindering the comprehensive exhibition of its authenticity. Addressing this challenge requires the establishment of a scientific and reasonable quality control system, which poses significant complexities due to the TCM unique attributes. Our research team conducted in-depth exploration of the elemental fingerprints of TCM, amassing a robust theoretical and practical foundation. In this review, we presented a comprehensive review of the core value, advanced technologies, and classic cases of elemental fingerprints. We introduced a novel perspective that integrated inorganic and organic components, overcoming traditional paradigms. The review analysis highlighted unique role of elemental fingerprints in revealing the scientific connotation of TCM. Furthermore, we proposed an innovative strategy for identifying key components, which effectively addressed the limitations of traditional methods and elevated the overall evaluation standards for TCM. This strategy was supported by emerging technologies such as artificial intelligence, metallomics, and hyperspectral imaging. Looking ahead, the application prospects of the combined strategy of elemental fingerprints and key components were promising. 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New vision for TCM quality control: elemental fingerprints and key ingredient combination strategy for identification and evaluation of TCMs
The quality control of Traditional Chinese Medicine (TCM) is crucial for ensuring its efficacy and safety. Traditional methods, however, have limitations in fully capturing the natural essence of TCM, thus hindering the comprehensive exhibition of its authenticity. Addressing this challenge requires the establishment of a scientific and reasonable quality control system, which poses significant complexities due to the TCM unique attributes. Our research team conducted in-depth exploration of the elemental fingerprints of TCM, amassing a robust theoretical and practical foundation. In this review, we presented a comprehensive review of the core value, advanced technologies, and classic cases of elemental fingerprints. We introduced a novel perspective that integrated inorganic and organic components, overcoming traditional paradigms. The review analysis highlighted unique role of elemental fingerprints in revealing the scientific connotation of TCM. Furthermore, we proposed an innovative strategy for identifying key components, which effectively addressed the limitations of traditional methods and elevated the overall evaluation standards for TCM. This strategy was supported by emerging technologies such as artificial intelligence, metallomics, and hyperspectral imaging. Looking ahead, the application prospects of the combined strategy of elemental fingerprints and key components were promising. It not only provided a solid foundation for the formulation of TCM quality control strategies but also introduced new methodologies and tools to the field of regulatory science and scientific oversight of TCM.
期刊介绍:
The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers.
A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.