基于可控光导接枝/脱落策略的糖聚合物刷的综合表征

IF 4.1 2区化学 Q2 POLYMER SCIENCE

Polymer Pub Date : 2024-10-28 DOI:10.1016/j.polymer.2024.127757

Al-Hassan S. Mahdy , Ibrahim M. Ammar , Shanmeng Lin , Kui Tan , Qi Xing , Jin Geng

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引用次数: 0

摘要

在此，我们提出了一种利用表面诱导光诱导电子/能量转移-可逆加成-断裂链转移（SI-PET-RAFT）聚合法在玻璃基底上自主调节糖聚合物刷构建和裂解的策略。该工艺包括用光可裂解分子处理链转移剂，并用 3-氨基丙基三乙氧基硅烷（APTES）将其连接到玻璃基底上。以 ZnTPP 作为光催化剂，聚合反应在 510 纳米波长下开始，糖聚合物刷可在 305 纳米波长的光下分离。这使得 GPC 和 NMR 表征成为可能，并证明了Đ <1.2的可控聚合物结构。与非聚糖表面相比，表面形成的聚糖（包括 D-葡萄糖和 D-甘露糖基聚合物）可增强 NCM460 细胞的粘附力，从而实现精确的细胞粘附和分离。这表明它有可能应用于组织工程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Comprehensive characterization of glycopolymer brushes based on controlled light-directed grafting/detachment strategy

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Comprehensive characterization of glycopolymer brushes based on controlled light-directed grafting/detachment strategy

Herein, we present a strategy for the autonomous regulation of glycopolymer brush construction and cleavage on glass substrates using surface-initiated photoinduced electron/energy transfer-reversible addition-fragmentation chain transfer (SI-PET-RAFT) polymerization. This process involves treating the chain transfer agent with a photocleavable moiety and linking it to glass substrates using 3-Aminopropyl triethoxysilane (APTES). Polymerization initiates at 510 nm with ZnTPP as a photocatalyst, and the glycopolymer brushes can be detached with 305 nm light. This allows GPC and NMR characterization, demonstrating controlled polymer structures with Đ <1.2. Glycopolymers formed on the surface, including d-glucose and d-mannose based polymers, enhance NCM460 cell adhesion compared to non-glycopolymer surfaces, enabling precise cell adhesion and detachment. This suggests potential applications in tissue engineering.

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来源期刊

Polymer 化学-高分子科学

CiteScore

7.90

自引率

8.70%

发文量

959

审稿时长

32 days

期刊介绍： Polymer is an interdisciplinary journal dedicated to publishing innovative and significant advances in Polymer Physics, Chemistry and Technology. We welcome submissions on polymer hybrids, nanocomposites, characterisation and self-assembly. Polymer also publishes work on the technological application of polymers in energy and optoelectronics. The main scope is covered but not limited to the following core areas: Polymer Materials Nanocomposites and hybrid nanomaterials Polymer blends, films, fibres, networks and porous materials Physical Characterization Characterisation, modelling and simulation* of molecular and materials properties in bulk, solution, and thin films Polymer Engineering Advanced multiscale processing methods Polymer Synthesis, Modification and Self-assembly Including designer polymer architectures, mechanisms and kinetics, and supramolecular polymerization Technological Applications Polymers for energy generation and storage Polymer membranes for separation technology Polymers for opto- and microelectronics.