癌症治疗中的杯突症纳米药物：新见解和未来展望

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2024-10-26 DOI:10.1016/j.ccr.2024.216284

Lu Wang , Jingxuan Piao , Hengkai Qi , Chu Qiao , Qiqiang Guo , Minjie Wei , Zhenhua Li

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引用次数: 0

摘要

铜突细胞增多症是一种由铜触发的新型程序性细胞死亡，最近已成为一种很有前景的癌症治疗靶点。以纳米药物为基础的杯突症靶向研究取得了重大进展，引起了人们的极大兴趣，并为开发新型疗法开辟了新途径。在这篇综述中，我们全面总结了铜的生物学特性、铜在癌症生物学中的关键作用以及铜氧化的分子机制。我们还深入探讨了纳米药物触发的铜突变的最新进展，这是创新治疗策略中一种有效的概念验证应用。最后，我们强调了未来的前景和挑战，包括癌症纳米药物的临床转化和杯突症介导的新范例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cuproptosis nanomedicine in cancer therapy: Novel insights and future perspectives

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Cuproptosis nanomedicine in cancer therapy: Novel insights and future perspectives

Cuproptosis, a new type of copper-triggered programmed cell death, has recently emerged as a promising target for cancer treatment. The nanomedicine-based targeting of cuproptosis has experienced significant advancements, attracting enormous interest and opening new avenues for developing novel therapeutics. In this review, we provide a comprehensive summary of the biology of copper, its critical roles in cancer biology, and the molecular mechanisms underlying cuproptosis. We also offer insight into recent progress in nanomedicine-triggered cuproptosis, a potent and proof-of-concept application in innovative therapeutic strategies. Finally, we highlight future perspectives and challenges, including the clinical translation of cancer nanomedicine and new cuproptosis-mediated emerging paradigms.

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.