如何为 T 细胞提供线粒体

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-10-28 DOI:10.1038/s41590-024-02008-3

Nicholas J. Bernard

引用次数: 0

摘要

线粒体功能衰竭和失调会限制T细胞的效应功能及其杀死实体瘤的能力，肿瘤细胞被认为利用了这一效应，通过隧道式纳米管连接（可长距离连接细胞的膜突起）将线粒体吸出免疫细胞。现在发表在《细胞》（Cell）杂志上的数据显示了如何在免疫治疗中利用这些纳米管来逆转线粒体的流动，以支持T细胞对肿瘤的效应功能。研究人员利用高度精细的场发射扫描电子显微镜观察到了这些将共培养的CD8+ T细胞与骨髓基质细胞（BMSC）连接起来的纳米管结构。此外，他们还利用共聚焦显微镜看到了纳米管内的线粒体，并确定了T细胞中的骨髓基质细胞供体线粒体。线粒体从 BMSC 转移到 CD8+ T 细胞的结果是线粒体含量增加，新陈代谢能力增强。受体T细胞能更有效地浸润肿瘤，在注射到小鼠体内时，其效应功能得到改善，肿瘤杀伤能力增强，而且在肿瘤微环境中不易衰竭。研究人员进一步转化了这些发现，展示了这种BMSC线粒体转移方法如何也能增强CD19嵌合抗原受体（CAR）T细胞：细胞 https://doi.org/10.1016/j.cell.2024.08.029 (2024)

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.