用于 RNA 环化的扩展工具包

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2024-10-28 DOI:10.1038/s41551-024-01262-y

Xiao Wang, Youkui Huang, Ling-Ling Chen

引用次数: 0

摘要

体外和细胞内合成环状 RNA 的优化方法，以及一种互补的 Cas9 去免疫方法，提高了 RNA 的持久性，降低了基因组工程和细胞工程应用中的免疫原性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Expanded toolkits for RNA circularization

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Expanded toolkits for RNA circularization

Optimized methods for the synthesis of circular RNA in vitro and in cells, and a complementary Cas9 de-immunization method, enhance RNA persistence and reduce immunogenicity for applications in genome engineering and cell engineering.

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.