制备 WELAN 并将其应用于 Pd(OAc)2 催化的铃木-宫浦交叉偶联反应

IF 2.3 4区化学 Q3 CHEMISTRY, PHYSICAL

Catalysis Letters Pub Date : 2024-09-22 DOI:10.1007/s10562-024-04815-7

Bishwajit Saikia

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引用次数: 0

摘要

在乙酸钯催化下，芳基/芳香族溴化物与芳基/替代芳基硼酸在纯净的 "印度楝树叶灰水提取物"（WELAN）中发生了无配体的 Suzukii-Miyaura 交叉偶联反应。该方法在无配体/外部碱/促进剂/有机介质的条件下，在室温空气中以极短的反应时间（5-60 分钟）在天然原料 WELAN 中进行反应，因此是现有方案的一种简单、温和、高效且极具成本效益的替代方法。在此发现，WELAN 是该交叉偶联反应的有效碱和反应介质，具有较高的周转次数 (TON)。本手稿还从理论上描述了 WELAN 催化交叉偶联反应的可能机理。

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Preparation and Application of WELAN to Pd(OAc)2-Catalyzed Suzuki–Miyaura Cross-Coupling Reaction

An extremely efficient green protocol for palladium acetate-catalysed ligand-free Suzuki–Miyaura cross-coupling reactions of aryl/heteroaryl bromides with aryl/substitute aryl boronic acids in neat ‘Water Extract of Leaf Ash of Neem’ (WELAN)’ was developed. This method offers a simple, mild, efficient and highly cost-effective alternative to the existing protocols since the reaction proceeds in natural feedstock WELAN at room temperature in air at very short reaction times (5–60 min) under ligand/external base/promoter/organic medium free conditions. Here WELAN has been found to be the effective base and reaction medium for this cross-coupling reaction with high turnover number (TON). This manuscript also theoretically depicts the probable mechanism of WELAN catalysed cross-coupling reaction.

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来源期刊

Catalysis Letters 化学-物理化学

CiteScore

5.70

自引率

3.60%

发文量

327

审稿时长

1 months

期刊介绍： Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis. The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.