人体尿液中存在 N,N'-取代对苯二胺衍生的醌类物质

IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Toxics Pub Date : 2024-10-11 DOI:10.3390/toxics12100733
Juxiu Huang, Hangbiao Jin, Yingying Zhu, Ruyue Guo, Lisha Zhou, Xiaoyu Wu
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引用次数: 0

摘要

人类暴露于各种 N,N'-取代对苯二胺衍生醌(PPDQ)的情况日益受到关注。最近的研究对人体尿液中的 N-苯基-N'-(1,3-二甲基丁基)-对苯二胺衍生醌(6PPDQ)进行了检测,以评估人体接触情况。然而,尚未对人体尿液中的其他 PPDQ 进行深入研究。本研究分析了中国台州 149 名健康人尿液中的六种 PPDQ。所有目标 PPDQ 均被检测到,其中女性尿液中的 6PPDQ(平均值为 2.4 ng/mL,p = 0.013)和 2,5-双(邻甲苯氨基)环己-2,5-二烯-1,4-二酮(平均值为 1.1 与 0.62 ng/mL;p = 0.027)明显高于男性。对于 CPPDQ(p < 0.01)和 6PPDQ(p < 0.01),随着参与者年龄的增长,尿液中的浓度会有所下降。对中国成年人每天通过尿液排出的 PPDQ 进行了估算。6PPDQ的平均排泄量最高,为81纳克/千克体重/天,范围从
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Presence of N, N'-Substituted p-Phenylenediamine-Derived Quinones in Human Urine.

Human exposure to various N,N'-substituted p-phenylenediamine-derived quinones (PPDQs) has been of increasing concern. Recent studies have examined N-phenyl-N'-(1,3-dimethylbutyl)-p-phenylenediamine-derived quinone (6PPDQ) in human urine to evaluate human exposure. However, other PPDQs in human urine have not been thoroughly investigated. This study analyzed six PPDQs in urine collected from 149 healthy individuals in Taizhou, China. All target PPDQs were detected, with 6PPDQ (mean 2.4 ng/mL, p = 0.013) and 2,5-bis(o-tolylamino)cyclohexa-2,5-diene-1,4-dione (mean 1.1 vs. 0.62 ng/mL; p = 0.027) were significantly higher in females compared to males. For CPPDQ (p < 0.01) and 6PPDQ (p < 0.01), a decrease was observed in urinary concentrations as participants aged. The daily excretion (DE) of PPDQs through urine was estimated for Chinese adults. The highest average DE was recorded for 6PPDQ at 81 ng/kg-bw/day, with a range from <0.5 to 475 ng/kg-bw/day. Following this, CPPDQ had a mean DE of 68 ng/kg-bw/day (range <0.5-516 ng/kg-bw/day), and 77PDQ had a mean DE of 30 ng/kg-bw/day (<0.5-481 ng/kg-bw/day). This study is the first to explore the presence of various PPDQs in human urinary samples, which is essential for assessing the potential health risks associated with these substances.

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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.
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