慢性胃炎的组织病理学特征及其与幽门螺旋杆菌感染的关系

Gargi Tignath Shukla, Sunita Yadav, Ajay Shukla, Krishna Kumar Yadav, Amit V Varma, Sirish Nandedekar, Mili Senger, Sudha Gupta
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引用次数: 0

摘要

背景/目的:幽门螺杆菌(H. pylori)感染是慢性胃炎(CG)最常见的病因,全球约有 50% 的人口受到感染。长期感染会增加发展为胃癌的风险。本研究采用更新悉尼系统(USS)评估了慢性胃炎的组织病理学变化,以估算幽门螺杆菌胃炎的患病率及其与其他组织学变量的相关性:本研究是一项前瞻性观察研究,在印度中部一家三级教学医院的病理科进行。研究时间为 2017 年 2 月至 2018 年 4 月。每位患者取两份前列腺活检样本,一份用于快速尿素酶测试,另一份用于常规组织病理学检查。所有样本均按照 USS 进行分析:在所有消化不良患者中,83.84%的患者患有胃癌。最常见的年龄组为 31-40 岁,男性居多。在109例有慢性胃炎组织病理学证据的胃前区活检中,分别有50例(45.87%)、10例(9.2%)、23例(21.10%)和11例(10.09%)出现中性粒细胞活动、肠化生、萎缩和淋巴聚集。幽门螺杆菌的感染率为 46.78%,其与慢性炎症和肠化生程度的关系具有统计学意义:结论:幽门螺杆菌与慢性炎症和肠化生程度密切相关。因此,本研究建议,如果在前胃活检中发现慢性炎症和肠化生,则应积极寻找幽门螺杆菌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological Features of Chronic Gastritis and its Association with Helicobacter pylori Infection.

Background/aims: A Helicobacter pylori (H. pylori) infection is the most common cause of chronic gastritis (CG), with approximately 50% of the world's population infected. Long-term infection increases the risk of progression to gastric cancer. This study evaluated the histopathological changes in CG using the Updated Sydney System (USS) to estimate the prevalence and correlation of H. pylori gastritis with other histological variables.

Methods: This research was a prospective observational study conducted in the Department of Pathology of a tertiary care teaching hospital in Central India. The study was conducted between Feb 2017 to April 2018. Two antral biopsies were taken per patient, one for a Rapid Urease Test and the second for routine histopathology. All samples were analyzed according to the USS.

Results: CG was found in 83.84% of total dyspeptic patients. The most common age group was 31-40 years, with a male preponderance. Of 109 gastric antral biopsies with histopathological evidence of chronic gastritis, neutrophilic activity, intestinal metaplasia, atrophy, and lymphoid aggregates were present in 50 (45.87%), 10 (9.2%), 23 (21.10%), and 11(10.09%) cases, respectively. The prevalence of H. pylori was 46.78%, and its association with the degree of chronic inflammation and intestinal metaplasia was statistically significant.

Conclusions: H. pylori was significantly associated with the degree of chronic inflammation and intestinal metaplasia. Hence, this study suggests a vigorous search for H. pylori should be initiated if chronic inflammation and intestinal metaplasia are seen in antral gastric biopsies.

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