与肠道制剂有关的急性胃病(按年龄分类):口服硫酸盐片剂与含抗坏血酸的 1 升聚乙二醇相比

Jin Young Yoon, Su Bee Park, Moon Hyung Lee, Min Seob Kwak, Jae Myung Cha
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引用次数: 0

摘要

背景/目的:1-L 聚乙二醇抗坏血酸盐(PEG/Asc)和口服硫酸盐片剂(OST)作为低容量肠道准备剂的使用逐渐增多。然而,这些药物可能会在肠道准备过程中诱发急性胃病,尤其是在老年人群中。本研究旨在比较 1-L PEG/Asc 和 OST 不同年龄段的急性胃病发生率以及疗效和安全性:这项回顾性研究纳入了在同一天接受食管胃十二指肠镜(EGD)和结肠镜筛查并使用 OST 或 1-L PEG/Asc 进行肠道准备的患者。我们收集了与急性胃病相关的胃肠镜检查结果、使用波士顿肠道准备量表(BBPS)进行的肠道清洁评分、息肉或腺瘤检出率(ADR)以及实验室参数:在 4711 名患者中,年轻组(18-49 岁)、中年组(50-64 岁)和老年组(≥65 岁)分别有 1758 人、2241 人和 712 人。在所有年龄组中,OST 组的急性胃病发生率均高于 1-L PEG/Asc 组。年轻组、中年组和老年组的 OST 和 1-L PEG/Asc 使用率分别为 42.9% 和 11.6%、41.2% 和 16.0%,以及 41.5% 和 16.4%。值得注意的是,在年轻组中,OST 组的 BBPS 和 ADR 总分显著高于 1-L PEG/Asc 组;但其他年龄组的 BBPS 和 ADR 总分没有差异:结论:在所有年龄组中,急性胃病与 OST 的相关性均高于 1-L PEG/Asc。因此,医生在进行肠道准备时应考虑到所有年龄组的急性胃病都与低容量药物有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute Gastropathy Associated with Bowel Preparation According to Age: Oral Sulfate Tablets versus 1-L Polyethylene Glycol with Ascorbic Acid.

Background/aims: The use of 1-L polyethylene glycol with ascorbate (PEG/Asc) and oral sulfate tablets (OST) as low-volume bowel preparation agents has gradually increased. However, these agents may induce acute gastropathy during bowel preparation, particularly in elderly populations. This study aimed to compare the incidence of acute gastropathy of 1-L PEG/Asc and OST according to age, as well as efficacy and safety.

Methods: This retrospective study included patients who underwent esophagogastroduodenoscopy (EGD) and colonoscopy for screening on the same day and underwent bowel preparation using OST or 1-L PEG/Asc. We collected EGD findings related to acute gastropathy, bowel-cleansing score using the Boston Bowel Preparation Scale (BBPS), polyp or adenoma detection rate (ADR), and laboratory parameters.

Results: Of 4,711 patients, 1,758, 2,241, and 712 were in the younger (18-49 years), middle-aged (50-64 years), and older (≥65 years) groups, respectively. In all age groups, the OST group had higher rates of acute gastropathy than the 1-L PEG/Asc group. The younger-, middle-, and older-aged groups had OST and 1-L PEG/Asc usage rates of 42.9% and 11.6%, 41.2% and 16.0%, and 41.5% and 16.4%, respectively. Notably, in the younger group, the total BBPS and ADR scores were significantly higher in the OST group than in the 1-L PEG/Asc group; however, these did not differ in the other age groups.

Conclusions: Acute gastropathy was more strongly associated with OST than with 1-L PEG/Asc in all age groups. Therefore, physicians should consider acute gastropathy associated with low-volume agents in all age groups when performing bowel preparation.

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