基因预测的生活方式因素对虚弱的影响：孟德尔随机研究的证据。

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-10-17 DOI:10.1016/j.archger.2024.105662

Min Xin , Wenxin Wang , Ming Zhou , Yuhan Geng , Hao Liu , Wenxi Luo , Gong zi Zhang , Liping Huang

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引用次数: 0

摘要

目的利用孟德尔随机化方法（MR）评估基因预测的生活方式因素与虚弱之间的因果关系：我们从对欧洲血统个体进行的全基因组关联研究中提取了汇总数据，研究了吸烟、饮酒、体力活动和久坐行为等生活方式因素。研究结果采用弗里德虚弱评分（FFS）和虚弱指数（FI）进行评估。我们进行了双样本单变量孟德尔随机化（SVMR）和多变量孟德尔随机化（MVMR），以同时评估独立的因果效应，主要采用反方差加权法进行估计。使用了多重敏感性和验证分析：IVW分析表明，吸烟会增加虚弱风险（FFS：β = 0.107，95 % CI = 0.057 to 0.156，P < 0.001；FI：β = 0.899，95 % CI = 0.016 to 0.191，P = 0.020）。剧烈运动或其他锻炼（SSOE）可降低虚弱风险（FFS：β = -0.473，95 % CI = -0.646 to -0.299，P < 0.001；FI：β = -0.423，95 % CI = -0.692 to -0.154，P = 0.002）。剧烈和中到剧烈的体育活动与较低的 FFS 显著相关，但对 FI 没有影响。增加看电视与更高的虚弱发生率有关（FFS：β = 0.227，95 % CI = 0.197 to 0.257，P <0.001；FI：β = 0.297，95 % CI = 0.249 to 0.346，P <0.001），在调整驾驶和电脑使用的 MVMR 中，这种影响仍然存在：本研究表明，减少吸烟、饮酒和体育锻炼有助于预防或控制体弱。

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Genetically-predicted effects of lifestyle factors on frailty: Evidence from Mendelian randomization study

Objective

To evaluate the causal relationships between genetically predicted lifestyle factors and frailty using Mendelian randomization(MR).

Methods

We extracted summary data from genome-wide association studies conducted among individuals of European ancestry, examining lifestyle factors such as smoking, alcohol consumption, physical activity, and sedentary behaviors. The outcomes were assessed using Fried Frailty Score (FFS) and Frailty Index (FI). We conducted 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR) to simultaneously assess the independent causal effects were primarily estimated using inverse variance weighted methods. Multiple sensitivity and validation analyzes were used.

Results

The IVW analyzes indicated that smoking increased frailty risk (FFS: β = 0.107, 95 % CI = 0.057 to 0.156, P < 0.001; FI: β = 0.899, 95 % CI = 0.016 to 0.191, P = 0.020.), this effect was amplified in the MVMR analysis after adjusting for alcohol consumption. Strenuous sports or other exercise(SSOE) reduced frailty risk (FFS: β = -0.473, 95 % CI = -0.646 to -0.299, P < 0.001; FI: β = -0.423, 95 % CI = -0.692 to -0.154, P = 0.002). Vigorous and moderate-to-vigorous physical activities were significantly related to lower FFS, although no effects were observed on FI. Increased television watching was linked to higher frailty incidence (FFS: β = 0.227, 95 % CI = 0.197 to 0.257, P < 0.001; FI: β = 0.297, 95 % CI = 0.249 to 0.346, P < 0.001), the impact remained persistent in MVMR adjusting for driving and computer use.

Conclusion

This study suggests that modifications in smoking, alcohol consumption, and physical activity may help prevent or manage frailty.

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.