衰老和衰老导致死亡的五因素理论。

IF 3.5 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Danko Obradovic
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引用次数: 0

摘要

这一新的衰老理论解释了衰老和衰老导致的死亡是由五个因素造成的,还解释了这些因素是如何相互关联并共同导致机体衰老和死亡的,并指出了许多事实有力地支持了这一理论。第一个因素是细胞结构发生的有害变化。第二个因素是成年生物的细胞分裂停止,导致无法恢复细胞结构。第三个因素是细胞在生物体生命过程中不会因有害变化的积累而死亡。第四个因素是干细胞无法通过用新细胞取代干细胞来再生组织,因为体细胞不会死亡,也没有信号刺激干细胞增殖并分化成新细胞来取代死亡细胞。第五个因素是,所有细胞都是由于机体的某项重要功能停止而突然死亡,而不是在生命过程中由于细胞结构发生有害变化而导致细胞功能下降而逐渐死亡,这将使干细胞能够再生组织并使身体保持年轻。另外,为了证明这一衰老理论的正确性,该理论还给出了它对五种因素演变的看法,根据这一理论,这五种因素会导致衰老,这为这一理论提供了强有力的支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Five-factor theory of aging and death due to aging
This new theory of aging explains that aging and death due to aging are due to five factors, and also explains how these factors are interconnected and jointly lead to aging and death of the organism, pointing to many facts that strongly support it. The first factor is the harmful changes that occur in cellular structures. The second factor is the cessation of cell division in adult organisms, which leads to the inability to restore cellular structures. The third factor is the feature that cells do not die due to the accumulation of harmful changes that occur in the cells during the life of the organism. The fourth factor is the inability of stem cells to regenerate tissue by replacing such cells with new ones, because somatic cells do not die and there are no signals that stimulate the proliferation of stem cells and their differentiation into new ones that would replace dead cells. The fifth factor is that all cells die suddenly, due to the cessation of one of the vital functions of the organism, and not gradually during life, due to a decrease in the functionality of cells caused by the introduction of harmful changes in cellular structures, which would allow stem cells to regenerate tissues and keep the body young. Also, to show that this aging theory is valid, the theory gives its view of the evolution of five factors, which according to this theory lead to aging, which gives strong support to this theory.
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来源期刊
CiteScore
7.30
自引率
5.00%
发文量
198
审稿时长
16 days
期刊介绍: Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.
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