Caspase-12 影响小鼠的软骨形成。

IF 2 3区 医学 Q2 ANATOMY & MORPHOLOGY
Barbora Veselá , Jana Bzdúšková , Alice Ramešová , Kateřina Holomková , Eva Matalová
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引用次数: 0

摘要

Caspase-12 是一种功能尚不十分明确的分子。虽然在各种组织中都发现了它的表达,但只有少数情况下描述了它的具体作用。其中包括 Caspase-12 在颅面发育过程中对小鼠骨细胞分化的影响。这项工作的重点是在软骨生长板形成之前通过软骨内骨化进行的四肢发育。这里首次描述了生长板软骨细胞在生理发育过程中的 Caspase-12。通过药理抑制,发现Caspase-12会影响软骨形成。在抑制caspase-12后,肢源微量培养物显示软骨形成结节的面积明显增加,基因表达也发生了变化,其中最显著的变化是Mmp9的减少。这些数据表明了caspase-12在软骨形成过程中的潜在新功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Caspase-12 affects chondrogenesis in mice
Caspase-12 is a molecule whose functions are still not well understood. Although its expression has been found in various tissues, specific roles have been described in only a few cases. These include the effect of caspase-12 on murine bone cell differentiation during craniofacial development. This work focused on the development of the limbs taking place through endochondral ossification, which precedes the formation of the cartilaginous growth plate. Caspase-12 was described here for the first time in growth plate chondrocytes during physiological development. Using pharmacological inhibition, caspase-12 was found to affect chondrogenesis. Limb-derived micromass cultures showed a significantly increased area of chondrogenic nodules after caspase-12 inhibition and there were changes in gene expression, the most significant of which was the reduction of Mmp9. These data point to potential new functions of caspase-12 in chondrogenesis.
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来源期刊
Annals of Anatomy-Anatomischer Anzeiger
Annals of Anatomy-Anatomischer Anzeiger 医学-解剖学与形态学
CiteScore
4.40
自引率
22.70%
发文量
137
审稿时长
33 days
期刊介绍: Annals of Anatomy publish peer reviewed original articles as well as brief review articles. The journal is open to original papers covering a link between anatomy and areas such as •molecular biology, •cell biology •reproductive biology •immunobiology •developmental biology, neurobiology •embryology as well as •neuroanatomy •neuroimmunology •clinical anatomy •comparative anatomy •modern imaging techniques •evolution, and especially also •aging
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