感度加权磁共振成像中脑微出血的自动量化:与血管风险因素、白质高密度负荷和认知功能的关联。

Ji Su Ko, Yangsean Choi, Eun Seon Jeong, Hyun-Jung Kim, Grace Yoojin Lee, Ji Eun Park, Namkug Kim, Ho Sung Kim
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引用次数: 0

摘要

背景和目的:训练和验证基于深度学习(DL)的脑微小出血(CMB)易感加权核磁共振成像分割模型;发现CMB、认知障碍和血管风险因素之间的关联:这项单一机构回顾性研究的参与者在 2023 年 1 月至 9 月期间接受了脑磁共振成像,以评估认知障碍。在训练 DL 模型时,使用了 nnU-Net 框架,未作任何修改。DL 模型的性能在独立的内部和外部验证数据集上进行了评估。线性回归分析用于发现对数变换的CMB数量、认知功能(迷你精神状态检查[MMSE])、白质高密度(WMH)负担和临床血管风险因素(年龄、性别、高血压、糖尿病、血脂状况和体重指数)之间的关联:对 DL 模型(n = 287)进行训练后,内部验证集(n = 67)的平均骰子得分为 0.73(95% CI,0.67-0.79),外部验证集(骰子得分 = 0.46,95% CI,0.33-0.59,n = 68)的平均骰子得分为 0.73(95% CI,0.67-0.79),具有稳健的分割性能。在一个时间上独立的临床数据集中(n = 448),年龄较大、高血压和 WMH 负荷与所有分布(总、叶、深和小脑;所有 P P P = .04)中的 CMB 数量显著相关:结论:DL模型对CMB具有稳健的分割性能。在所有分布中,CMB 与 WMH 负荷呈显著正相关。WMH负荷和CMB数量的增加与认知功能的下降有关:缩写:CMB = 脑微出血;DL = 深度学习;DSC = 骰子相似系数;MMSE = 迷你精神状态检查;SVD = 小血管疾病;SWI = 易感加权图像;WMH = 白质高密度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Automated Quantification of Cerebral Microbleeds in SWI: Association with Vascular Risk Factors, White Matter Hyperintensity Burden, and Cognitive Function.

Background and purpose: The amount and distribution of cerebral microbleeds (CMB) are important risk factors for cognitive impairment. Our objective was to train and validate a deep learning (DL)-based segmentation model for cerebral microbleeds (CMBs) on SWI and to find associations among CMB, cognitive impairment, and vascular risk factors.

Materials and methods: Participants in this single-institution retrospective study underwent brain MRI to evaluate cognitive impairment between January and September 2023. For training the DL model, the nnU-Net framework was used without modifications. The performance of the DL model was evaluated on independent internal and external validation data sets. Linear regression analysis was used to find associations among log-transformed CMB numbers, cognitive function (Mini-Mental Status Examination [MMSE]), white matter hyperintensity (WMH) burden, and clinical vascular risk factors (age, sex, hypertension, diabetes, lipid profiles, and body mass index).

Results: Training of the DL model (n = 287) resulted in a robust segmentation performance with an average Dice score of 0.73 (95% CI, 0.67-0.79) in an internal validation set (n = 67) and modest performance in an external validation set (Dice score = 0.46; 95% CI, 0.33-0.59; n = 68). In a temporally independent clinical data set (n = 448), older age, hypertension, and WMH burden were significantly associated with CMB numbers in all distributions (total, lobar, deep, and cerebellar; all P < .01). The MMSE was significantly associated with hyperlipidemia (β = 1.88; 95% CI, 0.96-2.81; P < .001), WMH burden (β = -0.17 per 1% WMH burden, 95% CI, -0.27-0.08; P < . 001), and total CMB number (β = -0.01 per 1 CMB, 95% CI, -0.02-0.001; P = .04) after adjusting for age and sex.

Conclusions: The DL model showed a robust segmentation performance for CMB. In all distributions, CMB had significant positive associations with WMH burden. Increased WMH burden and CMB numbers were associated with decreased cognitive function.

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