通过粘连蛋白发出长程并列信号,促进细胞集体定向。

IF 9.4 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Peizheng Wu, Shogo Sawaki, Kei Yamauchi, Kazuki Yokota, Masataka Hakamada, Mamoru Mabuchi
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引用次数: 0

摘要

许多生命现象,如发育、形态发生、组织重塑和伤口愈合,通常都是由细胞集体的有序定向迁移所驱动的。然而,当细胞随机定向或有序定向的集体细胞中存在局部无序时,虽然经常出现各种运动模式(如整体旋转和局部漩涡)和/或各种运动模式(如径向模式和手性模式),但细胞迁移无法有序进行。因此,控制细胞定向以确保集合细胞的有序迁移非常重要。在这里,我们发现,在集体细胞定向中起关键作用的不是力的传递,而是通过粘附素发出的并列信号。令人惊讶的是,细胞定向的并粘蛋白信号可传递到塑料盘上未直接受到机械刺激的细胞,距离致动器最远可达 7 毫米。本研究表明,即使是微弱的机械刺激,也能通过并神经信号远距离传递,而无需力的传递。长距离并肾上腺素信号可能在各种生命现象中发挥重要作用。意义说明:共肾上腺素信号是一种直接依赖于细胞-细胞接触的信号,在机械传感、机械传导和细胞集体行为等细胞行为中发挥着重要作用,但人们对共肾上腺素信号的认识还不够。本研究证明,用于细胞集体定向的共生信号是通过粘连蛋白远距离传递的。据我们所知,这是首次报道长距离并列信号。这一发现可能有助于阐明发育、形态发生、组织重塑和伤口愈合等各种生命现象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Long range juxtacrine signalling through cadherin for collective cell orientation

Long range juxtacrine signalling through cadherin for collective cell orientation
Many life phenomena, such as development, morphogenesis, tissue remodelling, and wound healing, are often driven by orderly and directional migration of collective cells. However, when cells are randomly oriented or localized disorder exists in orderly oriented collective cells, cell migration cannot occur in an orderly manner although various motion modes such as global rotation and local swirling and/or various motion patterns such as radial pattern and chiral pattern often occur. Therefore, it is important to control cell orientation to ensure the orderly migration of collective cells. Here, we show that it is not force transmission, but juxtacrine signalling through cadherin that plays a critical role in the orientation of collective cells. Surprisingly, juxtacrine signalling for cell orientation reached cells on a plastic dish that were not directly subjected to mechanical stimulation, up to 7 mm away from the actuator. The present study suggests that even weak mechanical stimulation is transmitted in a long range without force transmission through juxtacrine signalling. The long range juxtacrine signalling might play an important role in various life phenomena.

Statement of significance

Juxtacrine signalling is direct cell-cell contact-dependent signalling, which plays a crucial role in cell behaviors such as mechanosensing, mechanotransduction and collective cell behaviors, however, there is not enough understanding about juxtacrine signalling. The present study has demonstrated that juxtacrine signalling for collective cell orientation is transmitted over a long range through cadherin. To the best of our knowledge, this is the first report of long range juxtacrine signalling. This finding may lead to the elucidation of various life phenomena such as development, morphogenesis, tissue remodelling, and wound healing.
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来源期刊
Acta Biomaterialia
Acta Biomaterialia 工程技术-材料科学:生物材料
CiteScore
16.80
自引率
3.10%
发文量
776
审稿时长
30 days
期刊介绍: Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.
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