补充乳香(Boswellia serrata L.)对 2 型糖尿病患者血糖指标和血脂状况的影响:系统综述和荟萃分析。

Frontiers in clinical diabetes and healthcare Pub Date : 2024-10-10 eCollection Date: 2024-01-01 DOI:10.3389/fcdhc.2024.1466408
Mehdi Karimi, Kimia Vakili, Pegah Rashidian, Seyedeh-Kiana Razavi-Amoli, Matin Akhbari, Kimia Kazemi
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引用次数: 0

摘要

背景:2 型糖尿病(T2DM)是一项重大的全球健康挑战,其发病率预计将以惊人的速度增长。近来,由于中草药安全性更高、不良反应更少,已被用于控制 T2DM。本研究旨在评估乳香对改善 T2DM 患者血糖指标和血脂状况的疗效:在 PubMed、Web of Science 和 Scopus 数据库中对截至 2024 年 4 月 30 日发表的所有相关研究进行了全面检索。使用血糖指标和血脂谱评估了补充乳香的效果。使用 Stata 软件提取数据并进行荟萃分析:该荟萃分析包括五项研究,共涉及 287 名 T2DM 患者。结果发现,与安慰剂或对照组相比,乳香能显著降低 T2DM 患者的血红蛋白 A1C (HbA1C)(SMD:-1.01;95%CI:-1.55 至 -0.46;P=0.00)、总胆固醇 (TC)(SMD:-0.44;95%CI:-0.68 至 -0.21;P=0.00)、甘油三酯(TG)(SMD:-0.42;95%CI:-0.66 至 -0.19);P=0.00)和低密度脂蛋白(LDL)(SMD:-0.43;95%CI:-0.73 至 -0.12);P=0.006)水平,同时降低空腹血糖(FBG),但不显著(SMD:-1.34,95%CI:-2.68 至 0.00;P=0.05)。值得注意的是,它对高密度脂蛋白(HDL)没有影响(SMD:0.56,95%CI:-0.14 至 -1.26; P=0.118):总之,补充乳香具有改善 T2DM 患者血糖指标和血脂状况的潜力。系统综述注册:crd.york.ac.uk/PROSPERO/display_record.php?RecordID=538347,标识符为 CRD42024538347。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of boswellia (Boswellia serrata L.) supplementation on glycemic markers and lipid profile in type 2 diabetic patients: a systematic review and meta-analysis.

Background: Type 2 diabetes mellitus (T2DM) is a significant global health challenge whose prevalence is projected to increase alarmingly. Recently, due to better safety and fewer adverse effects, herbal medicines have been used to manage T2DM. This study aimed to evaluate the efficacy of boswellia in improving glycemic markers and lipid profiles in T2DM patients.

Methods: A comprehensive search was conducted on the PubMed, Web of Science, and Scopus databases for all relevant studies published up to April 30, 2024. The effects of boswellia supplementation were evaluated using glycemic markers and lipid profiles. The data were extracted and meta-analyzed using Stata software.

Results: This meta-analysis included five studies with a total of 287 patients with T2DM. It was found that boswellia in patients with T2DM compared to the placebo or control group significantly reduced hemoglobin A1C (HbA1C) (SMD: -1.01; 95%CI: -1.55 to -0.46; P=0.00), total cholesterol (TC) (SMD: -0.44; 95%CI: -0.68 to -0.21; P=0.00), Triglycerides (TG) (SMD: -0.42; 95%CI: -0.66 to -0.19); P=0.00) and low-density lipoprotein (LDL) (SMD: -0.43; 95%CI: -0.73 to -0.12); P=0.006) levels, while reduced fasting blood glucose (FBG) but it was not significant (SMD: -1.34, 95%CI: -2.68 to 0.00; P=0.05). Notably, it did not affect high-density lipoprotein (HDL) (SMD: 0.56, 95%CI: -0.14 to -1.26; P=0.118).

Conclusion: In summary, boswellia supplementation has the potential to improve glycemic markers and lipid profiles in patients with T2DM. It may help diabetic patients in addition to a controlled diet and other treatments.

Systematic review registration: crd.york.ac.uk/PROSPERO/display_record.php?RecordID=538347, identifier CRD42024538347.

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