用奥马珠单抗治疗食物依赖性运动诱发过敏性休克(FDEIA)的病例报告。

IF 3.3 Q2 ALLERGY
Frontiers in allergy Pub Date : 2024-10-11 eCollection Date: 2024-01-01 DOI:10.3389/falgy.2024.1472320
Sara Mohamed, Sherin Thalappil, Ramzy Mohamed Ali
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引用次数: 0

摘要

食物依赖性运动诱发过敏性休克(FDEIA)是一种罕见而复杂的临床症状,即特定食物与体力活动相结合会诱发过敏反应,即使食物过敏原和运动都可以单独耐受。小麦是导致小麦依赖性运动诱发过敏性休克(WDEIA)最常见的罪魁祸首食物。由于小麦依赖性过敏性休克发作难以预测,且缺乏经批准的预防性药物,因此治疗小麦依赖性过敏性休克极具挑战性。本报告介绍了一例通过在治疗方案中添加奥马珠单抗而成功控制症状的 WDEIA 年轻女性患者。据我们所知,这是首例以奥马珠单抗为主要适应症治疗食物依赖性运动诱发过敏性休克(FDEIA)的病例。我们还总结了 FDEIA 的病理生理学、诊断和治疗。对于受 FDEIA 影响的患者来说,提高意识和创新治疗方法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case report of food-dependent exercise-induced anaphylaxis (FDEIA) treated with omalizumab.

Food-dependent exercise-induced anaphylaxis (FDEIA) is a rare and complex clinical condition in which allergic reactions are triggered by specific foods combined with physical activity, even though the food allergen and exercise are tolerated individually. Wheat is the most common culprit food leading to wheat dependent exercise induced anaphylaxis (WDEIA). Management of FDEIA is challenging due to the unpredictability of attacks and the lack of approved prophylactic medications. This report presents a case of successful symptom control in a young woman with WDEIA through the addition of omalizumab to the treatment regimen. To our knowledge, this is the first reported case of food-dependent exercise-induced anaphylaxis (FDEIA) treated with omalizumab as the primary indication. We also summarize the pathophysiology, diagnosis and treatment of FDEIA. The need for heightened awareness and innovative therapeutic approaches is crucial for those affected by FDEIA.

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CiteScore
2.80
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