Ahmed Abu-Zaid, Saleh A K Saleh, Heba M Adly, Saeed Baradwan, Abdullah M Alharran, Mshal Alhatm, Mooza M Alzayed, Muteb N Alotaibi, Abdulbadih Rabih Saad, Hessa Mohammed Alfayadh, Mohammed Abuzaid, Osama Alomar
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The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose-response analyses were performed.</p><p><strong>Results: </strong>Seventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06-0.70, n = 15, I<sup>2</sup> = 67.03). However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI -0.02-0.03, n = 9, I<sup>2</sup> = 48.12), FSH (WMD -0.02, 95% CI -0.57-0.53, n = 7, I<sup>2</sup> = 48.72), LH (WMD -0.09, 95% CI -0.30-0.12, n = 8, I<sup>2</sup> = 0.00), SHBG (WMD 0.73, 95% CI -1.14-2.61, n = 10, I<sup>2</sup> = 69.05), FAI (WMD -0.92, 95% CI -2.12-0.27, n = 6, I<sup>2</sup> = 0.00), and estradiol (WMD -0.02, 95% CI -2.95-2.92, n = 5, I<sup>2</sup> = 20.63).</p><p><strong>Conclusion: </strong>This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D's effects on other reproductive hormone parameters.</p>","PeriodicalId":72832,"journal":{"name":"Diseases (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506788/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review.\",\"authors\":\"Ahmed Abu-Zaid, Saleh A K Saleh, Heba M Adly, Saeed Baradwan, Abdullah M Alharran, Mshal Alhatm, Mooza M Alzayed, Muteb N Alotaibi, Abdulbadih Rabih Saad, Hessa Mohammed Alfayadh, Mohammed Abuzaid, Osama Alomar\",\"doi\":\"10.3390/diseases12100228\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol.</p><p><strong>Methods: </strong>We systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose-response analyses were performed.</p><p><strong>Results: </strong>Seventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06-0.70, n = 15, I<sup>2</sup> = 67.03). However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI -0.02-0.03, n = 9, I<sup>2</sup> = 48.12), FSH (WMD -0.02, 95% CI -0.57-0.53, n = 7, I<sup>2</sup> = 48.72), LH (WMD -0.09, 95% CI -0.30-0.12, n = 8, I<sup>2</sup> = 0.00), SHBG (WMD 0.73, 95% CI -1.14-2.61, n = 10, I<sup>2</sup> = 69.05), FAI (WMD -0.92, 95% CI -2.12-0.27, n = 6, I<sup>2</sup> = 0.00), and estradiol (WMD -0.02, 95% CI -2.95-2.92, n = 5, I<sup>2</sup> = 20.63).</p><p><strong>Conclusion: </strong>This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. 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引用次数: 0
摘要
背景：最新研究表明，维生素 D 会影响男性生殖功能，缺乏维生素 D 会导致不育。本综述评估了补充维生素 D 对男性生育能力的影响，重点关注总睾酮、游离睾酮、游离雄激素指数 (FAI)、卵泡刺激素 (FSH)、黄体生成素 (LH)、性激素结合球蛋白 (SHBG) 和雌二醇：我们系统地检索了 Medline、Web of Science、Cochrane Library 和 Scopus 从开始到 2024 年 7 月涉及成年男性的随机对照试验 (RCT)。这些研究主要关注生殖激素参数，采用随机效应荟萃分析和加权平均差（WMD）进行分析。证据质量采用 ROB2 和 GRADE 进行评估。进行了元回归和剂量反应分析：17项研究符合定量分析标准。维生素 D 补充剂可显著提高总睾酮水平（WMD 0.38，95% CI 0.06-0.70，n = 15，I2 = 67.03）。然而，维生素 D 对其他激素参数没有明显影响：游离睾酮（WMD 0.00，95% CI -0.02-0.03，n = 9，I2 = 48.12）、FSH（WMD -0.02，95% CI -0.57-0.53，n = 7，I2 = 48.72）、LH（WMD -0.09，95% CI -0。30-0.12, n = 8, I2 = 0.00）、SHBG（WMD 0.73, 95% CI -1.14-2.61, n = 10, I2 = 69.05）、FAI（WMD -0.92, 95% CI -2.12-0.27, n = 6, I2 = 0.00）和雌二醇（WMD -0.02, 95% CI -2.95-2.92, n = 5, I2 = 20.63）：这项荟萃分析表明，补充维生素 D 可提高男性的总睾酮水平。结论：这项荟萃分析表明，补充维生素 D 可提高男性的总睾酮水平，但要确定维生素 D 对其他生殖激素参数的影响，还需要进一步开展设计良好的 RCT 研究。
The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review.
Background: Recent studies indicate that vitamin D impacts male reproductive function, with deficiency linked to infertility. This review evaluates the effect of vitamin D supplementation on male fertility, focusing on total testosterone, free testosterone, the free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex-hormone-binding globulin (SHBG), and estradiol.
Methods: We systematically searched Medline, Web of Science, Cochrane Library, and Scopus from their inception until July 2024 for randomized controlled trials (RCTs) involving adult males. The primary focus of these studies was on reproductive hormone parameters, analyzed using a random-effects meta-analysis and weighted mean difference (WMD). Evidence quality was assessed using ROB2 and GRADE. Meta-regression and dose-response analyses were performed.
Results: Seventeen studies met the criteria for quantitative analysis. Vitamin D supplementation significantly increased total testosterone levels (WMD 0.38, 95% CI 0.06-0.70, n = 15, I2 = 67.03). However, it had no significant effect on other hormone parameters: free testosterone (WMD 0.00, 95% CI -0.02-0.03, n = 9, I2 = 48.12), FSH (WMD -0.02, 95% CI -0.57-0.53, n = 7, I2 = 48.72), LH (WMD -0.09, 95% CI -0.30-0.12, n = 8, I2 = 0.00), SHBG (WMD 0.73, 95% CI -1.14-2.61, n = 10, I2 = 69.05), FAI (WMD -0.92, 95% CI -2.12-0.27, n = 6, I2 = 0.00), and estradiol (WMD -0.02, 95% CI -2.95-2.92, n = 5, I2 = 20.63).
Conclusion: This meta-analysis shows that vitamin D supplementation may increase total testosterone levels in men. However, further well-designed RCTs are needed to determine vitamin D's effects on other reproductive hormone parameters.
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