代谢综合征中的槲皮素补充剂:在啮齿动物模型中与 Zbtb16 基因变异的营养遗传学相互作用。

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY
Adéla Kábelová, Hana Malínská, Irena Marková, Martina Hüttl, František Liška, Blanka Chylíková, Ondřej Šeda
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引用次数: 0

摘要

背景:槲皮素是一种有望治疗代谢综合征(MetS)相关异常的植物化学物质。本研究旨在使用两种不同基因的 MetS 模型,探讨补充槲皮素后的形态计量学、代谢、转录组学和营养遗传学反应,这两种模型仅在与 MetS 相关的 Zbtb16 基因(Zinc Finger And BTB Domain Containing 16)变异上存在差异:结果:补充槲皮素可显著降低两个研究菌株腹膜后脂肪组织的相对重量。经槲皮素处理后,内脏(附睾)脂肪量减少,同时棕色脂肪量增加,这只在SHR品系中观察到。虽然两个品系的血清甘油三酯水平都有所下降,但只有SHR-Zbtb16-Q大鼠的游离脂肪酸水平有所下降。两个受试品系的血清总胆固醇水平均未受到槲皮素的影响。虽然棕色脂肪组织转录组没有发生明显变化,但补充槲皮素会导致腹膜后白色脂肪组织的基因表达发生明显变化,尤其是在SHR-Zbtb16-Q大鼠中:结论:服用槲皮素可改善某些与 MetS 相关的特征;然而,根据 Zbtb16 基因的具体变异,治疗效果会出现微妙的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quercetin supplementation in metabolic syndrome: nutrigenetic interactions with the Zbtb16 gene variant in rodent models.

Background: Quercetin is a promising phytochemical in treating abnormalities associated with metabolic syndrome (MetS). This study aimed to explore the morphometric, metabolic, transcriptomic, and nutrigenetic responses to quercetin supplementation using two genetically distinct MetS models that only differ in the variant of the MetS-related Zbtb16 gene (Zinc Finger And BTB Domain Containing 16).

Results: Quercetin supplementation led to a significant reduction in the relative weight of retroperitoneal adipose tissue in both investigated strains. A decrease in visceral (epididymal) fat mass, accompanied by an increase in brown fat mass after quercetin treatment, was observed exclusively in the SHR strain. While the levels of serum triglycerides decreased within both strains, the free fatty acids levels decreased in SHR-Zbtb16-Q rats only. The total serum cholesterol levels were not affected by quercetin in either of the two tested strains. While there were no significant changes in brown adipose tissue transcriptome, quercetin supplementation led to a pronounced gene expression shift in white retroperitoneal adipose tissue, particularly in SHR-Zbtb16-Q.

Conclusion: Quercetin administration ameliorates certain MetS-related features; however, the efficacy of the treatment exhibits subtle variations depending on the specific variant of the Zbtb16 gene.

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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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