强直性脊柱炎与神经退行性疾病之间的关系：系统回顾与荟萃分析。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine Pub Date : 2025-01-01 DOI:10.1016/j.jbspin.2024.105793

Anling Luo , Qin Yang , Zhao Zhang, Yujia Yang, Xuzi Li, Yiting Deng, Li He, Muke Zhou

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引用次数: 0

摘要

背景：越来越多的证据表明，强直性脊柱炎（AS）和神经退行性疾病（NDs）存在免疫功能障碍和炎症紊乱的重叠机制。然而，两者之间的确切相关性仍不清楚。关于强直性脊柱炎和神经退行性疾病之间的关系，不同研究的结果并不一致：本研究旨在探讨强直性脊柱炎与 NDs 风险之间的关系：我们检索了电子数据库，包括 PubMed、EMBASE、Web of Science 和 Cochrane Central Register of Controlled Trials，以确定 2024 年 4 月 10 日之前发表的报告 NDs 风险与 AS 之间关系的研究。估计了汇总的几率比（OR）和相应的 95% 置信区间（CI）。所有分析均使用Stata V.12.0软件进行：共纳入了 10 项研究中的 15 项比较，涉及 851 936 名参与者。结果显示，强直性脊柱炎患者的玖玖彩票网正规吗风险高于非强直性脊柱炎患者（OR 1.36，95% CI 1.15-1.60，P < 0.001）。此外，亚组分析表明，强直性脊柱炎与帕金森病（PD）发病风险增加有关（OR 1.55，95% CI 1.31-1.83，P <0.001），而与阿尔茨海默病（AD）和痴呆症（分别为OR 1.22，95% CI 0.96-1.55，P = 0.098；OR 1.34，95% CI 0.96-1.87，P = 0.089）没有相关性：目前的荟萃分析确定强直性脊柱炎是玖玖彩票android客户端发病的一个风险因素。临床医生应该意识到这些疾病之间的潜在关联。有必要开展进一步研究，以确认强直性脊柱炎与 NDs 之间的因果关系和潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Association between ankylosing spondylitis and neurodegenerative diseases: Systematic review and meta-analysis

Background

Increasing evidence indicates the mechanism of overlapping immune dysfunction and inflammation disorder shared by ankylosing spondylitis (AS) and neurodegenerative diseases (NDs). However, the exact correlation between the two is still unclear. Different studies have reported inconsistent results about how AS and NDs are related.

Objective

This study aimed to investigate the association between AS and risk of NDs.

Methods

We searched electronic databases including PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify studies reporting relationship between NDs risk and AS published before April 10th, 2024. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were estimated. All analyses were conducted using Stata V.12.0 software.

Results

A total of 15 comparisons out of 10 studies involving 851,936 participants were included. The results showed that the risk of NDs was higher among AS patients than those who were not (OR: 1.36, 95% CI: 1.15–1.60, P < 0.001). In addition, subgroup analysis showed that AS was associated with an increased risk of Parkinson's disease (PD) development (OR: 1.55, 95% CI: 1.31–1.83, P < 0.001), whereas there is no observed association with Alzheimer's disease (AD) and dementia (OR: 1.22, 95% CI: 0.96–1.55, P = 0.098; OR: 1.34, 95% CI: 0.96–1.87, P = 0.089, respectively).

Conclusion

The current meta-analysis identified AS as a risk factor for the development of NDs. Clinicians should be aware of the potential association between these diseases. Further research is necessary to confirm the causal relationship and underlying mechanisms between AS and NDs.

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来源期刊

Joint Bone Spine 医学-风湿病学

CiteScore

4.50

自引率

11.90%

发文量

184

审稿时长

25 days

期刊介绍： Bimonthly e-only international journal, Joint Bone Spine publishes in English original research articles and all the latest advances that deal with disorders affecting the joints, bones, and spine and, more generally, the entire field of rheumatology. All submitted manuscripts to the journal are subjected to rigorous peer review by international experts: under no circumstances does the journal guarantee publication before the editorial board makes its final decision. (Surgical techniques and work focusing specifically on orthopedic surgery are not within the scope of the journal.)Joint Bone Spine is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.