与其他疾病不同，2 型糖尿病是 COVID-19 后新发重度抑郁症的风险因素。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2024-10-21 DOI:10.1016/j.jpsychores.2024.111963

Matthieu Gasnier , Anne-Lise Lecoq , Tài Pham , Luc Morin , François Radiguer , Eugénie Gosset-Grainville , Marie Quinque , Wassim Najib Alaoui , Eric Deflesselle , Walid Choucha , Samy Figueiredo , Mohamad Zaidan , Laurent Savale , David Montani , Xavier Monnet , Laurent Becquemont , Emmanuelle Corruble , Romain Colle

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引用次数: 0

摘要

目的：目前尚不清楚COVID前的医疗状况是否是COVID后重度抑郁发作（MDE）的风险因素。我们旨在确定哪些 COVID 前的医疗状况是 COVID-19 住院后重度抑郁发作的风险因素：我们在法国 Bicêtre 医院对 COVID-19 住院 6 个月后进行评估的 650 名患者队列中开展了一项巢式回顾性病例队列研究。研究人员从病历中提取了 COVID-19 前的九种疾病（高血压、肥胖、2 型糖尿病、心脏病、呼吸系统疾病、肾病、免疫缺陷、肿瘤和肝病）。MDE 采用 DSM-5 疾病结构化临床访谈-医师版（SCID-5-CV）进行评估。进行了二元和多元分析，以确定哪些COVID前的疾病是COVID后新发MDE的独立风险因素：患者平均年龄为 62.8（15.8）岁，258（39.7%）人为女性；301（46.3%）人患有高血压，205（32.4%）人患有肥胖症，186（28.6%）人患有 2 型糖尿病。有 36 名患者（5.5%）被诊断为新发 MDE。与其他病症相比，2 型糖尿病与新发 MDE 显著相关（OR = 2.51 [1.19-5.29]）：结论：与COVID前的其他病症不同，2型糖尿病是COVID后MDE的风险因素。2型糖尿病患者在因COVID-19住院后应进行MDE筛查。

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Unlike other medical conditions, type 2 diabetes is a risk factor for new-onset major depression after COVID-19

Objective

It is unclear whether pre-COVID medical conditions are risk factors for post-COVID major depressive episode (MDE). We aimed to determine which pre-COVID medical conditions are risk factors for post-COVID MDE after a hospitalization for COVID-19.

Methods

We conducted a nested retrospective case-cohort study within a cohort of 650 patients evaluated six months after hospitalization for COVID-19 at Bicêtre hospital, France. Nine medical conditions present before COVID-19 (High blood pressure, obesity, type 2 diabetes, cardiac, respiratory and renal disease, immune deficiency, neoplasia and liver disease) were extracted from medical records. MDE was assessed using the Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV). Bivariate and multivariable analyses were performed to determine which pre-COVID medical conditions are independent risk factors for post-COVID new-onset MDE.

Results

Patients mean age was 62.8 (15.8), 258 (39.7 %) were women; 301 (46.3 %) had high blood pressure, 205 (32.4 %) had obesity, and 186 (28.6 %) had type 2 diabetes. Thirty-six (5.5 %) patients were diagnosed with a new-onset MDE. In contrast to other medical conditions, type 2 diabetes was significantly associated with new-onset MDE (OR = 2.51 [1.19–5.29]).

Conclusion

Unlike other pre-COVID medical conditions, type 2 diabetes is a risk factor for post-COVID MDE. Patients with type 2 diabetes should be screened for MDE after a hospitalization for COVID-19.

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来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.