一只患有嗜酸性粒细胞增多症的猫患上了伴有嗜酸性粒细胞浸润和硬化性纤维增生的结节性 T 细胞淋巴瘤。

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Medical Science Pub Date : 2024-10-22 DOI:10.1292/jvms.24-0225

Tamami Suzuki, Jumpei Yamazaki, Kouta Yamaguchi, Keisuke Aoshima, Takashi Kimura

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引用次数: 0

摘要

一只 8 岁的阉割雄性混血猫腹部出现不明原因的肿块，伴有嗜酸性粒细胞增多。尸检显示，猫全身淋巴结轻度至重度肿大，肺部有多个结节。组织病理学显示，淋巴结出现严重的纤维增生，大量嗜酸性粒细胞和较少肿瘤细胞浸润，呈现大尺寸淋巴细胞形态。肺部、肝脏、肾脏、胃部和肠道都出现了嗜酸性粒细胞浸润和纤维化的肿瘤细胞转移病灶。免疫组化显示，肿瘤细胞的 CD3 阳性，B 细胞和肥大细胞标记物阴性。因此，确诊为伴有嗜酸性粒细胞浸润和硬化性纤维增生的 T 细胞淋巴瘤。

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Nodal T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia in a cat with eosinophilia.

An 8-year-old castrated male mixed-breed cat presented with an abdominal mass of unknown origin, accompanied by eosinophilia. Autopsy revealed mild-to-severe enlargement of lymph nodes throughout the body and multiple nodules in the lungs. Histopathologically, the lymph nodes showed severe fibroplasia and infiltration by a large number of eosinophils and fewer tumor cells, exhibiting large-sized lymphoid cell morphology. Metastatic lesions of tumor cells with eosinophilic infiltration and fibrosis were observed in the lungs, liver, kidneys, stomach, and intestines. Immunohistochemistry revealed that the tumor cells were positive for CD3 and negative for B cell and mast cell markers. Thus, T-cell lymphoma with eosinophilic infiltration and sclerosing fibroplasia was diagnosed.

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来源期刊

Journal of Veterinary Medical Science 农林科学-兽医学

CiteScore

2.30

自引率

8.30%

发文量

230

审稿时长

9-18 weeks

期刊介绍： JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.