Cássia da Luz Goulart, Guilherme Peixoto Tinoco Arêas, Mauricio Milani, Fernanda Facioli Dos Reis Borges, Juliana Ribeiro Magalhães, Guilherme Dionir Back, Audrey Borghi-Silva, Luciano Fonseca Lemos Oliveira, André Ribeiro de Paula, Carolina Coimbra Marinho, Déborah Pereira Prado, Celso Nascimento de Almeida, Cristiane Maria Carvalho Costa Dias, Vinícius Afonso Gomes, Luiz Eduardo Fonteles Ritt, Leandro Tolfo Franzoni, Ricardo Stein, Mansueto Gomes Neto, Gerson Cipriano Junior, Fernando Almeida-Val
{"title":"COVID-19 后 30 个月肺功能和心肺反应的性别差异：巴西多中心研究","authors":"Cássia da Luz Goulart, Guilherme Peixoto Tinoco Arêas, Mauricio Milani, Fernanda Facioli Dos Reis Borges, Juliana Ribeiro Magalhães, Guilherme Dionir Back, Audrey Borghi-Silva, Luciano Fonseca Lemos Oliveira, André Ribeiro de Paula, Carolina Coimbra Marinho, Déborah Pereira Prado, Celso Nascimento de Almeida, Cristiane Maria Carvalho Costa Dias, Vinícius Afonso Gomes, Luiz Eduardo Fonteles Ritt, Leandro Tolfo Franzoni, Ricardo Stein, Mansueto Gomes Neto, Gerson Cipriano Junior, Fernando Almeida-Val","doi":"10.3390/ijerph21101293","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim</b>: (I) to verify if there are sex differences in respiratory function, respiratory muscle strength, and effort limitation in individuals recovered from severe acute COVID-19 30 months after the initial infection, and (II) to evaluate the influence of length of stay on cardiorespiratory capacity among men and women. <b>Methods</b>: Cross-sectional observational multicentric study with participants from five Brazilian states (São Paulo, Amazonas, Minas Gerais, Bahia, and Brasília). We assessed lung function and respiratory muscle strength by maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and cardiorespiratory fitness by cardiopulmonary exercise test (CPET). <b>Results</b>: 86 individuals were stratified by sex (48 women and 38 men). Females had significantly longer hospitalization for acute COVID-19 (<i>p</i> < 0.05) and showed a marked reduction in MIP (cmH<sub>2</sub>O and % predicted). Regarding the CPET, women presented lower V˙O<sub>2</sub>% predicted, O<sub>2</sub> pulse, and oxygen uptake efficiency slope (OUES, % predicted) (<i>p</i> < 0.05). In addition, women also had greater abnormal combinations between RER < 1.10, OUES < 80% predicted, VE/VVM < 15% [3 (6.2%)] and V˙O<sub>2</sub>% predicted < 80%, V˙E/V˙CO<sub>2</sub> slope and V˙O<sub>2</sub>/workload < 8.4 mL/min/W [8 (17%)]. The regression analysis showed a significant influence of age, length of hospitalization (< and >10 days), and FEV<sub>1</sub>/FVC (%) on the V˙O<sub>2</sub> peak (mL·kg<sup>-1</sup>·min<sup>-1</sup>). Secondarily, we found that women hospitalized for more than 10 days had worse O<sub>2</sub> pulse (<i>p</i> = 0.03), OUES % predicted (<i>p</i> < 0.001), and worse V˙O<sub>2</sub>% predicted (<i>p</i> < 0.009). <b>Conclusion</b>: Women exhibited more pronounced impairments in several key indicators of cardiopulmonary function 30 months post-infection.</p>","PeriodicalId":49056,"journal":{"name":"International Journal of Environmental Research and Public Health","volume":"21 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507074/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex-Based Differences in Pulmonary Function and Cardiopulmonary Response 30 Months Post-COVID-19: A Brazilian Multicentric Study.\",\"authors\":\"Cássia da Luz Goulart, Guilherme Peixoto Tinoco Arêas, Mauricio Milani, Fernanda Facioli Dos Reis Borges, Juliana Ribeiro Magalhães, Guilherme Dionir Back, Audrey Borghi-Silva, Luciano Fonseca Lemos Oliveira, André Ribeiro de Paula, Carolina Coimbra Marinho, Déborah Pereira Prado, Celso Nascimento de Almeida, Cristiane Maria Carvalho Costa Dias, Vinícius Afonso Gomes, Luiz Eduardo Fonteles Ritt, Leandro Tolfo Franzoni, Ricardo Stein, Mansueto Gomes Neto, Gerson Cipriano Junior, Fernando Almeida-Val\",\"doi\":\"10.3390/ijerph21101293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim</b>: (I) to verify if there are sex differences in respiratory function, respiratory muscle strength, and effort limitation in individuals recovered from severe acute COVID-19 30 months after the initial infection, and (II) to evaluate the influence of length of stay on cardiorespiratory capacity among men and women. <b>Methods</b>: Cross-sectional observational multicentric study with participants from five Brazilian states (São Paulo, Amazonas, Minas Gerais, Bahia, and Brasília). We assessed lung function and respiratory muscle strength by maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and cardiorespiratory fitness by cardiopulmonary exercise test (CPET). <b>Results</b>: 86 individuals were stratified by sex (48 women and 38 men). Females had significantly longer hospitalization for acute COVID-19 (<i>p</i> < 0.05) and showed a marked reduction in MIP (cmH<sub>2</sub>O and % predicted). Regarding the CPET, women presented lower V˙O<sub>2</sub>% predicted, O<sub>2</sub> pulse, and oxygen uptake efficiency slope (OUES, % predicted) (<i>p</i> < 0.05). In addition, women also had greater abnormal combinations between RER < 1.10, OUES < 80% predicted, VE/VVM < 15% [3 (6.2%)] and V˙O<sub>2</sub>% predicted < 80%, V˙E/V˙CO<sub>2</sub> slope and V˙O<sub>2</sub>/workload < 8.4 mL/min/W [8 (17%)]. The regression analysis showed a significant influence of age, length of hospitalization (< and >10 days), and FEV<sub>1</sub>/FVC (%) on the V˙O<sub>2</sub> peak (mL·kg<sup>-1</sup>·min<sup>-1</sup>). Secondarily, we found that women hospitalized for more than 10 days had worse O<sub>2</sub> pulse (<i>p</i> = 0.03), OUES % predicted (<i>p</i> < 0.001), and worse V˙O<sub>2</sub>% predicted (<i>p</i> < 0.009). <b>Conclusion</b>: Women exhibited more pronounced impairments in several key indicators of cardiopulmonary function 30 months post-infection.</p>\",\"PeriodicalId\":49056,\"journal\":{\"name\":\"International Journal of Environmental Research and Public Health\",\"volume\":\"21 10\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11507074/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Environmental Research and Public Health\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.3390/ijerph21101293\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Research and Public Health","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.3390/ijerph21101293","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sex-Based Differences in Pulmonary Function and Cardiopulmonary Response 30 Months Post-COVID-19: A Brazilian Multicentric Study.
Aim: (I) to verify if there are sex differences in respiratory function, respiratory muscle strength, and effort limitation in individuals recovered from severe acute COVID-19 30 months after the initial infection, and (II) to evaluate the influence of length of stay on cardiorespiratory capacity among men and women. Methods: Cross-sectional observational multicentric study with participants from five Brazilian states (São Paulo, Amazonas, Minas Gerais, Bahia, and Brasília). We assessed lung function and respiratory muscle strength by maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and cardiorespiratory fitness by cardiopulmonary exercise test (CPET). Results: 86 individuals were stratified by sex (48 women and 38 men). Females had significantly longer hospitalization for acute COVID-19 (p < 0.05) and showed a marked reduction in MIP (cmH2O and % predicted). Regarding the CPET, women presented lower V˙O2% predicted, O2 pulse, and oxygen uptake efficiency slope (OUES, % predicted) (p < 0.05). In addition, women also had greater abnormal combinations between RER < 1.10, OUES < 80% predicted, VE/VVM < 15% [3 (6.2%)] and V˙O2% predicted < 80%, V˙E/V˙CO2 slope and V˙O2/workload < 8.4 mL/min/W [8 (17%)]. The regression analysis showed a significant influence of age, length of hospitalization (< and >10 days), and FEV1/FVC (%) on the V˙O2 peak (mL·kg-1·min-1). Secondarily, we found that women hospitalized for more than 10 days had worse O2 pulse (p = 0.03), OUES % predicted (p < 0.001), and worse V˙O2% predicted (p < 0.009). Conclusion: Women exhibited more pronounced impairments in several key indicators of cardiopulmonary function 30 months post-infection.
期刊介绍：
International Journal of Environmental Research and Public Health (IJERPH) (ISSN 1660-4601) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes, and short communications in the interdisciplinary area of environmental health sciences and public health. It links several scientific disciplines including biology, biochemistry, biotechnology, cellular and molecular biology, chemistry, computer science, ecology, engineering, epidemiology, genetics, immunology, microbiology, oncology, pathology, pharmacology, and toxicology, in an integrated fashion, to address critical issues related to environmental quality and public health. Therefore, IJERPH focuses on the publication of scientific and technical information on the impacts of natural phenomena and anthropogenic factors on the quality of our environment, the interrelationships between environmental health and the quality of life, as well as the socio-cultural, political, economic, and legal considerations related to environmental stewardship and public health.
The 2018 IJERPH Outstanding Reviewer Award has been launched! This award acknowledge those who have generously dedicated their time to review manuscripts submitted to IJERPH. See full details at http://www.mdpi.com/journal/ijerph/awards.
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