D H Nguyen, D Garcia, H Mirghani, P Giraud, O Laccourreye
{"title":"法国对八旬老人 cT1-2N0M0 声门鳞状细胞癌喉部保守治疗的 STROBE 分析。","authors":"D H Nguyen, D Garcia, H Mirghani, P Giraud, O Laccourreye","doi":"10.1016/j.anorl.2024.10.004","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To document conservative laryngeal treatment for cT12N0M0 glottic squamous cell carcinoma (SCC) in octogenarians in France in the 21st century.</p><p><strong>Material and methods: </strong>Retrospective observational study comparing a cohort of 38 octogenarians (Group A) to a control cohort of 107 septuagenarians (Group B), with isolated cT12N0M0 glottic SCC, consecutively managed between 2000 and 2018 at a single French university hospital center. The main endpoints were 5-year actuarial overall and disease-free survival and causes of death, compared between groups. Accessory endpoints were 5-year actuarial local control and laryngeal preservation. 93% of patients were followed until death or for a minimum 5years. The STROBE guideline was used. The significance threshold was set at P<0.005.</p><p><strong>Results: </strong>The only significant difference in demographic, oncologic and treatment variables between groups was a higher mean Charlson index in Group A (P=0.004). Five-year actuarial survival, at 79% overall, did not significantly differ between groups A and B (80% and 79%, respectively; P=0.30). Five-year actuarial disease-free survival, at 74% overall, did not significantly differ between groups (77% and 73%; P=0.42). Intercurrent disease accounted for 44% of causes of death, with cardiovascular etiology in 71% of cases. Five-year actuarial local control, at 76% overall, did not significantly differ between groups (80% and 75%; P=0.41). Salvage treatment for local recurrence yielded a 94% overall local control rate: 98% in Group A and 93% in Group B. Five-year actuarial laryngeal preservation rate, at 92%, did not significantly differ between groups (90% and 98%; P=0.20).</p><p><strong>Conclusion: </strong>Conservative laryngeal treatment for cT12N0M0 SCC in octogenarians yielded the same results as in septuagenarians. Improvement in survival will depend on management and monitoring of comorbidity, and particularly cardiovascular comorbidity.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A STROBE analysis of conservative laryngeal treatment in France for cT1-2N0M0 glottic squamous cell carcinoma in octogenarians.\",\"authors\":\"D H Nguyen, D Garcia, H Mirghani, P Giraud, O Laccourreye\",\"doi\":\"10.1016/j.anorl.2024.10.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To document conservative laryngeal treatment for cT12N0M0 glottic squamous cell carcinoma (SCC) in octogenarians in France in the 21st century.</p><p><strong>Material and methods: </strong>Retrospective observational study comparing a cohort of 38 octogenarians (Group A) to a control cohort of 107 septuagenarians (Group B), with isolated cT12N0M0 glottic SCC, consecutively managed between 2000 and 2018 at a single French university hospital center. The main endpoints were 5-year actuarial overall and disease-free survival and causes of death, compared between groups. Accessory endpoints were 5-year actuarial local control and laryngeal preservation. 93% of patients were followed until death or for a minimum 5years. The STROBE guideline was used. The significance threshold was set at P<0.005.</p><p><strong>Results: </strong>The only significant difference in demographic, oncologic and treatment variables between groups was a higher mean Charlson index in Group A (P=0.004). Five-year actuarial survival, at 79% overall, did not significantly differ between groups A and B (80% and 79%, respectively; P=0.30). Five-year actuarial disease-free survival, at 74% overall, did not significantly differ between groups (77% and 73%; P=0.42). Intercurrent disease accounted for 44% of causes of death, with cardiovascular etiology in 71% of cases. Five-year actuarial local control, at 76% overall, did not significantly differ between groups (80% and 75%; P=0.41). Salvage treatment for local recurrence yielded a 94% overall local control rate: 98% in Group A and 93% in Group B. Five-year actuarial laryngeal preservation rate, at 92%, did not significantly differ between groups (90% and 98%; P=0.20).</p><p><strong>Conclusion: </strong>Conservative laryngeal treatment for cT12N0M0 SCC in octogenarians yielded the same results as in septuagenarians. 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引用次数: 0
摘要
摘要记录21世纪法国八旬老人喉部保守治疗cT12N0M0声门鳞状细胞癌（SCC）的情况：回顾性观察研究比较了38名八旬老人（A组）和107名七旬老人（B组），他们都患有孤立的cT12N0M0声门鳞状细胞癌，2000年至2018年期间在一家法国大学医院中心连续接受治疗。主要终点是5年精算总生存期、无病生存期和死亡原因，并在组间进行比较。辅助终点为5年精算局部控制率和喉保留率。93%的患者接受随访直至死亡或至少5年。采用的是 STROBE 指南。显著性阈值设定为 PResults：各组在人口统计学、肿瘤学和治疗变量方面的唯一显著差异是 A 组的平均 Charlson 指数更高（P=0.004）。A 组和 B 组的五年精算存活率（总存活率为 79%）无显著差异（分别为 80% 和 79%；P=0.30）。A组和B组的五年精算无病生存率为74%，无明显差异（分别为77%和73%；P=0.42）。并发症占死亡原因的44%，心血管病因占71%。五年的精算局部控制率为76%，两组间无显著差异（80%和75%；P=0.41）。对局部复发进行挽救治疗的总体局部控制率为 94%：A组为98%，B组为93%。5年精算喉保留率为92%，组间无显著差异（90%和98%；P=0.20）：结论：八旬老人的 cT12N0M0 SCC 喉部保守治疗与七旬老人的效果相同。生存率的提高将取决于对合并症，尤其是心血管合并症的管理和监测。
A STROBE analysis of conservative laryngeal treatment in France for cT1-2N0M0 glottic squamous cell carcinoma in octogenarians.
Objectives: To document conservative laryngeal treatment for cT12N0M0 glottic squamous cell carcinoma (SCC) in octogenarians in France in the 21st century.
Material and methods: Retrospective observational study comparing a cohort of 38 octogenarians (Group A) to a control cohort of 107 septuagenarians (Group B), with isolated cT12N0M0 glottic SCC, consecutively managed between 2000 and 2018 at a single French university hospital center. The main endpoints were 5-year actuarial overall and disease-free survival and causes of death, compared between groups. Accessory endpoints were 5-year actuarial local control and laryngeal preservation. 93% of patients were followed until death or for a minimum 5years. The STROBE guideline was used. The significance threshold was set at P<0.005.
Results: The only significant difference in demographic, oncologic and treatment variables between groups was a higher mean Charlson index in Group A (P=0.004). Five-year actuarial survival, at 79% overall, did not significantly differ between groups A and B (80% and 79%, respectively; P=0.30). Five-year actuarial disease-free survival, at 74% overall, did not significantly differ between groups (77% and 73%; P=0.42). Intercurrent disease accounted for 44% of causes of death, with cardiovascular etiology in 71% of cases. Five-year actuarial local control, at 76% overall, did not significantly differ between groups (80% and 75%; P=0.41). Salvage treatment for local recurrence yielded a 94% overall local control rate: 98% in Group A and 93% in Group B. Five-year actuarial laryngeal preservation rate, at 92%, did not significantly differ between groups (90% and 98%; P=0.20).
Conclusion: Conservative laryngeal treatment for cT12N0M0 SCC in octogenarians yielded the same results as in septuagenarians. Improvement in survival will depend on management and monitoring of comorbidity, and particularly cardiovascular comorbidity.
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