皮肤乳头细胞:从基础研究到转化应用。

IF 3.6 3区 生物学 Q1 BIOLOGY
He-Li Zhang, Xi-Xi Qiu, Xin-Hua Liao
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引用次数: 0

摘要

头发作为皮肤的附属物,可以抵御紫外线辐射和机械损伤,调节体温。头发还能反映一个人的健康状况,是表达个性的重要方式。脱发和白发是许多人的重大心理负担。头发由毛囊产生,毛囊完全由其底部的真皮乳头(DP)控制。真皮乳头细胞(DPC)由一群特化的间充质细胞组成,在胚胎发育早期通过与上皮前体细胞相互作用诱导毛囊的形成。毛囊成熟后,它们通过分泌各种因子继续调节毛发的生长周期、颜色、大小和类型。DPCs 具有干细胞特征,可在体外培养和扩增。DPCs 表达多种干性相关因子,只需使用两种甚至一种山中因子,就能将它们重编程为诱导多能干细胞(iPSCs)。DPCs是皮肤衍生前体(SKPs)的重要来源。当与上皮干细胞结合时,它们可以重建皮肤和毛囊,参与包括DP和真皮鞘在内的真皮层再生。当 DPCs 被植入表皮和真皮之间时,可诱导无毛皮肤上新毛囊的形成。皮下注射 DPCs 及其外泌体可促进毛发生长。这篇综述总结了DP的体内功能;强调了DPCs在细胞疗法中的潜力,尤其是在治疗脱发方面;并讨论了该领域从基础研究到转化应用所面临的挑战和最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dermal Papilla Cells: From Basic Research to Translational Applications.

As an appendage of the skin, hair protects against ultraviolet radiation and mechanical damage and regulates body temperature. It also reflects an individual's health status and serves as an important method of expressing personality. Hair loss and graying are significant psychosocial burdens for many people. Hair is produced from hair follicles, which are exclusively controlled by the dermal papilla (DP) at their base. The dermal papilla cells (DPCs) comprise a cluster of specialized mesenchymal cells that induce the formation of hair follicles during early embryonic development through interaction with epithelial precursor cells. They continue to regulate the growth cycle, color, size, and type of hair after the hair follicle matures by secreting various factors. DPCs possess stem cell characteristics and can be cultured and expanded in vitro. DPCs express numerous stemness-related factors, enabling them to be reprogrammed into induced pluripotent stem cells (iPSCs) using only two, or even one, Yamanaka factor. DPCs are an important source of skin-derived precursors (SKPs). When combined with epithelial stem cells, they can reconstitute skin and hair follicles, participating in the regeneration of the dermis, including the DP and dermal sheath. When implanted between the epidermis and dermis, DPCs can induce the formation of new hair follicles on hairless skin. Subcutaneous injection of DPCs and their exosomes can promote hair growth. This review summarizes the in vivo functions of the DP; highlights the potential of DPCs in cell therapy, particularly for the treatment of hair loss; and discusses the challenges and recent advances in the field, from basic research to translational applications.

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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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