剧烈运动大鼠小脑皮层细胞和纤维结构的变化

IF 3.6 3区 生物学 Q1 BIOLOGY
Evgenii Balakin, Ksenia Yurku, Viacheslav Kuropatkin, Alexander Izotov, Valeriya Nakhod, Vasiliy Pustovoyt
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引用次数: 0

摘要

超过神经系统功能能力的过度运动会导致小脑神经结构的过度激活。这反过来又会导致细胞内资源耗竭,并使小脑细胞和纤维的结构发生渐进性变化。这些退行性变化可能导致小脑功能障碍,包括协调、平衡和运动功能的恶化。为了保持小脑和整个神经系统的健康和功能,人们需要避免过度劳累,并有足够的时间进行恢复。在对照组动物中发现了三种主要类型的浦肯野细胞。强迫游泳试验后,动物的梨状细胞、颗粒细胞、节间神经元和神经胶质细胞发生了明显的形态学变化。特别是颗粒细胞的极度退化表现为融合成团。这些变化表明,小脑神经变性是对过度运动的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes in the Cyto- and Fibroarchitectonics of the Cerebellar Cortex in Rats Subjected to Extreme Physical Activity.

Physical overexertion surpassing the functional capacity of the nervous system causes the hyperactivation of the neural structures of the cerebellum. In turn, it causes the depletion of intracellular resources and progressive structural changes in cerebellar cells and fibers. These degenerative changes may lead to cerebellar dysfunction, including the worsening of coordination, balance, and motor functions. In order to maintain the health and functioning of the cerebellum and the nervous system in general, one needs to avoid physical overexertion and have enough time to recover. Three major types of Purkinje cells were identified in control group animals. After the forced swimming test, animals had significant morphological changes in pyriform cells, granule cells, internuncial neurons, and neuroglial cells. In particular, the extreme degeneration of granule cells was manifested via their fusion into conglomerates. These changes demonstrate that neurodegeneration in the cerebellum takes place in response to physical overexertion.

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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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