氧化锌纳米材料在光学生物传感器和氧化锌纳米材料增强生物检测中的原理和应用。

IF 4.9 3区 工程技术 Q1 CHEMISTRY, ANALYTICAL
Marion Ryan C Sytu, Jong-In Hahm
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引用次数: 0

摘要

迄今为止,在增强型光学生物检测中开发和应用氧化锌纳米材料的研究取得了重大成就。人们成功地利用氧化锌纳米材料无与伦比的光学特性及其减小的尺寸,突破了传统光学生物传感器和光学生物检测平台对多种生物分析物的检测极限。氧化锌纳米材料在光学生物传感器中的应用已证明可改善传感器的主要性能特征,如检测极限和动态范围。此外,氧化锌的所有纳米材料形式,从 0 维(0D)、1D 到 2D 纳米结构,都已被证明是有用的,从而确保了其在功能性生物传感器中的多功能性。氧化锌作为一种重要的生物传感元素,不仅在组合方面,而且在单个纳米材料方面都得到了评估,这有利于实现生物传感器和生物设备的高度微型化和微创化。此外,将纳米材料融入生物传感器已被证明可用于多种光学检测模式,如吸收、比色、荧光、近带边发射、深层发射、化学发光、表面蒸发波、耳语画廊模式、有损模式共振、表面等离子体共振和表面增强拉曼散射。迄今为止,这些基于氧化锌纳米材料的光学生物传感器的检测能力非常令人鼓舞,在某些情况下,可以对其他方法无法测量的超痕量生物分析物进行定量分析。因此,预计这一新兴领域的研究工作将持续进行,其科学和技术影响将在未来大幅增长。本综述以全面、系统的方式对基于氧化锌纳米材料的光学生物传感器领域的研究工作进行了及时和急需的回顾。本综述中的专题讨论按照上述不同的光学检测模式组织,并根据生物传感器中使用的氧化锌纳米结构的尺寸进一步分组。在概述了特定光学检测模式之后,详细介绍了对增强生物检测至关重要的氧化锌纳米材料的独特性能。随后,针对约 40 种不同的生物分析物讨论了氧化锌纳米材料的具体生物传感应用,并确定了氧化锌纳米材料在生物分析物检测中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Principles and Applications of ZnO Nanomaterials in Optical Biosensors and ZnO Nanomaterial-Enhanced Biodetection.

Significant research accomplishments have been made so far for the development and application of ZnO nanomaterials in enhanced optical biodetection. The unparalleled optical properties of ZnO nanomaterials and their reduced dimensionality have been successfully exploited to push the limits of conventional optical biosensors and optical biodetection platforms for a wide range of bioanalytes. ZnO nanomaterial-enabled advancements in optical biosensors have been demonstrated to improve key sensor performance characteristics such as the limit of detection and dynamic range. In addition, all nanomaterial forms of ZnO, ranging from 0-dimensional (0D) and 1D to 2D nanostructures, have been proven to be useful, ensuring their versatile fabrication into functional biosensors. The employment of ZnO as an essential biosensing element has been assessed not only for ensembles but also for individual nanomaterials, which is advantageous for the realization of high miniaturization and minimal invasiveness in biosensors and biodevices. Moreover, the nanomaterials' incorporations into biosensors have been shown to be useful and functional for a variety of optical detection modes, such as absorption, colorimetry, fluorescence, near-band-edge emission, deep-level emission, chemiluminescence, surface evanescent wave, whispering gallery mode, lossy-mode resonance, surface plasmon resonance, and surface-enhanced Raman scattering. The detection capabilities of these ZnO nanomaterial-based optical biosensors demonstrated so far are highly encouraging and, in some cases, permit quantitative analyses of ultra-trace level bioanalytes that cannot be measured by other means. Hence, steady research endeavors are expected in this burgeoning field, whose scientific and technological impacts will grow immensely in the future. This review provides a timely and much needed review of the research efforts made in the field of ZnO nanomaterial-based optical biosensors in a comprehensive and systematic manner. The topical discussions in this review are organized by the different modes of optical detection listed above and further grouped by the dimensionality of the ZnO nanostructures used in biosensors. Following an overview of a given optical detection mode, the unique properties of ZnO nanomaterials critical to enhanced biodetection are presented in detail. Subsequently, specific biosensing applications of ZnO nanomaterials are discussed for ~40 different bioanalytes, and the important roles that the ZnO nanomaterials play in bioanalyte detection are also identified.

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来源期刊
Biosensors-Basel
Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.60
自引率
14.80%
发文量
983
审稿时长
11 weeks
期刊介绍: Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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