炎症性肠病儿童的早期症状:对后续骨矿物质缺乏症的影响

IF 2 4区 医学 Q2 PEDIATRICS
Mariusz Olczyk, Agnieszka Frankowska, Marcin Tkaczyk, Anna Socha-Banasiak, Elżbieta Czkwianianc
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引用次数: 0

摘要

背景:炎症性肠病(IBD)与影响骨代谢的多种因素有关。本研究旨在比较克罗恩病(CD)和溃疡性结肠炎(UC)患者确诊时的临床表现和诊断参数,并评估其与后续骨质紊乱的关系:方法:对最近诊断出患有 IBD 的 80 名儿童进行了血液化验(包括钙磷代谢)和粪便化验(包括钙蛋白)。此外,还对其中 25 名儿童的骨密度测量结果进行了评估:结果:腹泻(p = 0.02)和血便(p < 0.001)在 UC 患者中更为常见,而发热在 CD 患者中更为常见(p = 0.003)。实验室检查显示,62.5%(50/80)的患者贫血,36.3%(29/80)的患者血小板增多。确诊时,女孩粪便中的钙蛋白水平较高(p = 0.02)。近一半的受检患者(12/25)发现骨质疏松,20%的患者(5/25)符合骨质疏松症的标准。诊断时的低钙水平与随后的骨质紊乱有关(p = 0.005)。77.8%的患者(56/80)检测出维生素 D 含量不足:结论:对 IBD 患儿进行早期疾病检测和适当的监测可降低患骨质疏松症等严重后果的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early Symptoms in Children with Inflammatory Bowel Disease: Implications for Subsequent Bone Mineral Deficiency.

Background: Inflammatory bowel disease (IBD) is associated with multiple factors that influence bone metabolism. This study aimed to compare the clinical manifestations and diagnostic parameters of patients with Crohn's disease (CD) and ulcerative colitis (UC) at the time of diagnosis, as well as to assess their relationship with subsequent bone disorders.

Methods: Blood tests (including calcium-phosphate metabolism) and fecal tests (including calprotectin) were performed in eighty children recently diagnosed with IBD. Additionally, the bone densitometry results were evaluated in 25 of them.

Results: Diarrhea (p = 0.02) and bloody stools (p < 0.001) were more frequent in patients with UC, whereas fever was more common in patients with CD (p = 0.003). Laboratory tests revealed anemia in 62.5% (50/80) and thrombocytosis in 36.3% (29/80). Higher calprotectin levels in the feces were found in girls at the time of diagnosis (p = 0.02). Osteopenia was detected in almost half of the examined patients (12/25), and 20% (5/25) met the criteria for osteoporosis. Low calcium levels at diagnosis were correlated with subsequent bone disorders (p = 0.005). Insufficient levels of vitamin D were detected in 77.8% (56/80).

Conclusions: Early disease detection and the appropriate monitoring of children with IBD may decrease the risk of serious consequences, including osteoporosis.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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