德国新诊断为抑郁症的青少年中抗抑郁药物处方的流行率。

IF 2 4区 医学 Q2 PEDIATRICS
Nimran Kaur, Corinna Doege, Karel Kostev
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引用次数: 0

摘要

背景介绍抑郁症是世界上最常见的精神疾病,全球每十名青少年中就有近三人患有抑郁症。本研究旨在评估德国被诊断患有抑郁症的青少年中开具抗抑郁药处方的流行率以及抗抑郁治疗的类型:这项回顾性队列研究基于 30 位儿童和青少年精神科医生提供的数据,纳入了 IQVIATM 疾病分析仪数据库中记录的 2010 年至 2022 年(索引日期)期间初次诊断为抑郁症的 13-17 岁青少年。卡普兰-梅耶曲线用于研究按年龄、性别和抑郁严重程度分层的抗抑郁药物处方一年累计发生率。多变量考克斯回归分析用于评估年龄、性别、抑郁严重程度、合并诊断和抗抑郁药物处方之间的关联:共有 6338 名青少年(平均年龄:16 岁,67% 为女性,59% 患有中度抑郁症)接受了研究。抗抑郁药物处方的累计发生率为 61%,并随着年龄的增长而增加,从 13 岁增加到 17 岁。氟西汀是处方最多的药物,其次是舍曲林、艾司西酞普兰、血清素和去甲肾上腺素再摄取抑制剂、草药和米氮平。在合并诊断的病症中,发现强迫症和进食障碍与抗抑郁药物处方显著相关:结论:年龄越大、抑郁严重程度越高、同时被诊断为强迫症或进食障碍与青少年的抗抑郁药物处方呈显著正相关。氟西汀是最常见的抑郁症处方药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of Antidepressant Prescription in Adolescents Newly Diagnosed with Depression in Germany.

Background: Depression is the most common mental illness in the world, found in nearly three in ten adolescents globally. This study aims to evaluate the prevalence of antidepressant prescriptions and the types of antidepressant therapy administered among adolescents diagnosed with depression in Germany.

Methods: This retrospective cohort study, based on data provided by 30 child and adolescent psychiatrists, included adolescents aged 13-17 years with an initial diagnosis of depression between 2010 and 2022 (index date) documented in the IQVIATM Disease Analyzer database. Kaplan-Meier curves were used to investigate the one-year cumulative incidence of antidepressant prescriptions stratified by age, sex, and depression severity. Multivariable Cox regression analyses were used to assess the association between age, sex, depression severity, co-diagnoses, and antidepressant drug prescription.

Results: A total of 6338 adolescents (mean age: 16 years, 67% female, 59% with moderate depression) were available. The cumulative incidence of antidepressant prescriptions was 61% and increased with age from 13 years old to 17 years old. Fluoxetine was the most prescribed drug, followed by Sertraline, Escitalopram, Serotonin and Norepinephrine reuptake inhibitors, herbal medications, and Mirtazapine. Obsessive-compulsive disorder and eating disorders were found to be significantly associated with antidepressant prescriptions within the spectrum of co-diagnosed conditions.

Conclusions: Higher age, depression severity, and a co-diagnosis of an obsessive-compulsive disorder or eating disorder were significantly positively associated with antidepressant prescriptions in adolescents. Fluoxetine was the most frequently prescribed drug for depression.

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来源期刊
Children-Basel
Children-Basel PEDIATRICS-
CiteScore
2.70
自引率
16.70%
发文量
1735
审稿时长
6 weeks
期刊介绍: Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries. The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.
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