Maria Kuksin, Valeska Bidault Jourdainne, Guillaume Rossignol, Philippe Aegerter, Géraldine Hery, Jean-Paul Teglas, Virginie Fouquet, Sophie Branchereau, Florent Guérin
{"title":"根据生物测量变量预测儿童和成人肝脏捐献者的全肝移植物重量。","authors":"Maria Kuksin, Valeska Bidault Jourdainne, Guillaume Rossignol, Philippe Aegerter, Géraldine Hery, Jean-Paul Teglas, Virginie Fouquet, Sophie Branchereau, Florent Guérin","doi":"10.3390/children11101248","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/objectives: </strong>In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.</p><p><strong>Methods: </strong>We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.</p><p><strong>Results: </strong>In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R<sup>2</sup> = 0.86 and <i>p</i>-value < 10<sup>-5</sup>. We also determined two models in adult donors using donor weight and height (R<sup>2</sup> = 0.33, <i>p</i> < 10<sup>-4</sup>) and donor weight and sternal height (R<sup>2</sup> = 0.38, <i>p</i> < 10<sup>-4</sup>). The models proved valid based on our external dataset of 245 patients from two institutions.</p><p><strong>Conclusions: </strong>In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.</p>","PeriodicalId":48588,"journal":{"name":"Children-Basel","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506035/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prediction of Whole Liver Graft Weight Based on Biometric Variables in Paediatric and Adult Liver Donors.\",\"authors\":\"Maria Kuksin, Valeska Bidault Jourdainne, Guillaume Rossignol, Philippe Aegerter, Géraldine Hery, Jean-Paul Teglas, Virginie Fouquet, Sophie Branchereau, Florent Guérin\",\"doi\":\"10.3390/children11101248\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/objectives: </strong>In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.</p><p><strong>Methods: </strong>We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.</p><p><strong>Results: </strong>In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R<sup>2</sup> = 0.86 and <i>p</i>-value < 10<sup>-5</sup>. We also determined two models in adult donors using donor weight and height (R<sup>2</sup> = 0.33, <i>p</i> < 10<sup>-4</sup>) and donor weight and sternal height (R<sup>2</sup> = 0.38, <i>p</i> < 10<sup>-4</sup>). The models proved valid based on our external dataset of 245 patients from two institutions.</p><p><strong>Conclusions: </strong>In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.</p>\",\"PeriodicalId\":48588,\"journal\":{\"name\":\"Children-Basel\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-10-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506035/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Children-Basel\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/children11101248\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Children-Basel","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/children11101248","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Prediction of Whole Liver Graft Weight Based on Biometric Variables in Paediatric and Adult Liver Donors.
Background/objectives: In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.
Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.
Results: In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R2 = 0.86 and p-value < 10-5. We also determined two models in adult donors using donor weight and height (R2 = 0.33, p < 10-4) and donor weight and sternal height (R2 = 0.38, p < 10-4). The models proved valid based on our external dataset of 245 patients from two institutions.
Conclusions: In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.
期刊介绍:
Children is an international, open access journal dedicated to a streamlined, yet scientifically rigorous, dissemination of peer-reviewed science related to childhood health and disease in developed and developing countries.
The publication focuses on sharing clinical, epidemiological and translational science relevant to children’s health. Moreover, the primary goals of the publication are to highlight under‑represented pediatric disciplines, to emphasize interdisciplinary research and to disseminate advances in knowledge in global child health. In addition to original research, the journal publishes expert editorials and commentaries, clinical case reports, and insightful communications reflecting the latest developments in pediatric medicine. By publishing meritorious articles as soon as the editorial review process is completed, rather than at predefined intervals, Children also permits rapid open access sharing of new information, allowing us to reach the broadest audience in the most expedient fashion.