Harnessing Available Evidence in Single-Case Experimental Studies: The Use of Multilevel Meta-Analysis.

The use of multilevel models to combine and compare the results of multiple single-case experimental design (SCED) studies has been proposed about two decades ago. Since then, the number of multilevel meta-analyses of SCED studies steadily increased, together with the complexity of multilevel models used. At the same time, many studies were done to empirically evaluate the approach in a variety of situations, and to study how the flexibility of multilevel models can be employed to account for many complexities that often are encountered in SCED research, such as autocorrelation, linear and nonlinear time trends, specific designs, external event effects, multiple outcomes, and heterogeneity. In this paper, we give a state-of-the-art of the multilevel approach, by making an overview of basic and more extended models, summarizing simulation results, and discussing some remaining issues.