Oumaïma Benkirane, Peter Simor, Olivier Mairesse, Philippe Peigneux
{"title":"睡眠片段调节认知疲劳的神经生理学相关因素","authors":"Oumaïma Benkirane, Peter Simor, Olivier Mairesse, Philippe Peigneux","doi":"10.3390/clockssleep6040041","DOIUrl":null,"url":null,"abstract":"<p><p>Cognitive fatigue (CF) is a critical factor affecting performance and well-being. It can be altered in suboptimal sleep quality conditions, e.g., in patients suffering from obstructive sleep apnea who experience both intermittent hypoxia and sleep fragmentation (SF). Understanding the neurophysiological basis of SF in healthy individuals can provide insights to improve cognitive functioning in disrupted sleep conditions. In this electroencephalographical (EEG) study, we investigated in 16 healthy young participants the impact of experimentally induced SF on the neurophysiological correlates of CF measured before, during, and after practice on the TloadDback, a working memory task tailored to each individual's maximal cognitive resources. The participants spent three consecutive nights in the laboratory two times, once in an undisrupted sleep (UdS) condition and once in an SF condition induced by non-awakening auditory stimulations, counterbalanced and performed the TloadDback task both in a high (HCL) and a low (LCL) cognitive load condition. EEG activity was recorded during wakefulness in the 5 min resting state immediately before and after, as well as during the 16 min of the TloadDback task practice. In the high cognitive load under a sleep-fragmentation (HCL/SF) condition, high beta power increased during the TloadDback, indicating heightened cognitive effort, and the beta and alpha power increased in the post- vs. pre-task resting state, suggesting a relaxation rebound. In the low cognitive load/undisturbed sleep (LCL/UdS) condition, low beta activity increased, suggesting a relaxed focus, as well as mid beta activity associated with active thinking. These findings highlight the dynamic impact of SF on the neurophysiological correlates of CF and underscore the importance of sleep quality and continuity to maintain optimal cognitive functioning.</p>","PeriodicalId":33568,"journal":{"name":"Clocks & Sleep","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503390/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sleep Fragmentation Modulates the Neurophysiological Correlates of Cognitive Fatigue.\",\"authors\":\"Oumaïma Benkirane, Peter Simor, Olivier Mairesse, Philippe Peigneux\",\"doi\":\"10.3390/clockssleep6040041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cognitive fatigue (CF) is a critical factor affecting performance and well-being. It can be altered in suboptimal sleep quality conditions, e.g., in patients suffering from obstructive sleep apnea who experience both intermittent hypoxia and sleep fragmentation (SF). Understanding the neurophysiological basis of SF in healthy individuals can provide insights to improve cognitive functioning in disrupted sleep conditions. In this electroencephalographical (EEG) study, we investigated in 16 healthy young participants the impact of experimentally induced SF on the neurophysiological correlates of CF measured before, during, and after practice on the TloadDback, a working memory task tailored to each individual's maximal cognitive resources. The participants spent three consecutive nights in the laboratory two times, once in an undisrupted sleep (UdS) condition and once in an SF condition induced by non-awakening auditory stimulations, counterbalanced and performed the TloadDback task both in a high (HCL) and a low (LCL) cognitive load condition. EEG activity was recorded during wakefulness in the 5 min resting state immediately before and after, as well as during the 16 min of the TloadDback task practice. In the high cognitive load under a sleep-fragmentation (HCL/SF) condition, high beta power increased during the TloadDback, indicating heightened cognitive effort, and the beta and alpha power increased in the post- vs. pre-task resting state, suggesting a relaxation rebound. In the low cognitive load/undisturbed sleep (LCL/UdS) condition, low beta activity increased, suggesting a relaxed focus, as well as mid beta activity associated with active thinking. These findings highlight the dynamic impact of SF on the neurophysiological correlates of CF and underscore the importance of sleep quality and continuity to maintain optimal cognitive functioning.</p>\",\"PeriodicalId\":33568,\"journal\":{\"name\":\"Clocks & Sleep\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503390/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clocks & Sleep\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/clockssleep6040041\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clocks & Sleep","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/clockssleep6040041","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
摘要
认知疲劳(CF)是影响工作表现和身心健康的一个关键因素。在睡眠质量不佳的情况下,例如患有阻塞性睡眠呼吸暂停的患者同时经历间歇性缺氧和睡眠片段(SF)时,认知疲劳会发生改变。了解健康人睡眠片段的神经生理学基础可为改善睡眠中断情况下的认知功能提供启示。在这项脑电图(EEG)研究中,我们以 16 名健康的年轻参与者为研究对象,调查了实验诱导的 SF 在 TloadDback(一种根据每个人最大认知资源量身定制的工作记忆任务)练习前、练习中和练习后对 CF 神经生理相关性的影响。受试者连续三个晚上在实验室中度过了两次,一次是在未中断睡眠(UdS)条件下,另一次是在非唤醒听觉刺激诱导的 SF 条件下,受试者在高认知负荷(HCL)和低认知负荷(LCL)条件下平衡地完成了 TloadDback 任务。在清醒状态下,在紧接着的 5 分钟静息状态和 16 分钟的 TloadDback 任务练习期间,记录了脑电图活动。在睡眠断裂的高认知负荷(HCL/SF)条件下,高β功率在TloadDback过程中增加,表明认知努力增加,β和α功率在任务后与任务前的休息状态下增加,表明放松反弹。在低认知负荷/无干扰睡眠(LCL/UdS)条件下,低β活动增加,表明注意力放松,而中β活动则与思维活跃有关。这些发现凸显了SF对CF神经生理学相关性的动态影响,并强调了睡眠质量和连续性对维持最佳认知功能的重要性。
Sleep Fragmentation Modulates the Neurophysiological Correlates of Cognitive Fatigue.
Cognitive fatigue (CF) is a critical factor affecting performance and well-being. It can be altered in suboptimal sleep quality conditions, e.g., in patients suffering from obstructive sleep apnea who experience both intermittent hypoxia and sleep fragmentation (SF). Understanding the neurophysiological basis of SF in healthy individuals can provide insights to improve cognitive functioning in disrupted sleep conditions. In this electroencephalographical (EEG) study, we investigated in 16 healthy young participants the impact of experimentally induced SF on the neurophysiological correlates of CF measured before, during, and after practice on the TloadDback, a working memory task tailored to each individual's maximal cognitive resources. The participants spent three consecutive nights in the laboratory two times, once in an undisrupted sleep (UdS) condition and once in an SF condition induced by non-awakening auditory stimulations, counterbalanced and performed the TloadDback task both in a high (HCL) and a low (LCL) cognitive load condition. EEG activity was recorded during wakefulness in the 5 min resting state immediately before and after, as well as during the 16 min of the TloadDback task practice. In the high cognitive load under a sleep-fragmentation (HCL/SF) condition, high beta power increased during the TloadDback, indicating heightened cognitive effort, and the beta and alpha power increased in the post- vs. pre-task resting state, suggesting a relaxation rebound. In the low cognitive load/undisturbed sleep (LCL/UdS) condition, low beta activity increased, suggesting a relaxed focus, as well as mid beta activity associated with active thinking. These findings highlight the dynamic impact of SF on the neurophysiological correlates of CF and underscore the importance of sleep quality and continuity to maintain optimal cognitive functioning.