孕期感染对经胎盘抗体转移的影响

IF 5.2 3区 医学 Q1 IMMUNOLOGY
Vaccines Pub Date : 2024-10-21 DOI:10.3390/vaccines12101199
Celeste Coler, Elana King-Nakaoka, Emma Every, Sophia Chima, Ashley Vong, Briana Del Rosario, Roslyn VanAbel, Kristina M Adams Waldorf
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引用次数: 0

摘要

孕期接种疫苗对于保护母亲和胎儿免受传染病的侵害非常重要。在新生儿适应性免疫系统发育期间,孕期通过胎盘转移的母体抗体可在新生儿出生后几个月内继续保护新生儿。有几种病原体已被证明会影响母体抗体的胎盘转移,包括人类免疫缺陷病毒、疟疾、严重急性呼吸系统综合征冠状病毒 2 和巨细胞病毒。本综述讨论了在母体感染的情况下导致经胎盘抗体转移减少的机制,如抗体糖基化谱的变化、母体高丙种球蛋白血症和胎盘损伤。流行病的发生频率越来越高,与过去相比,现在的孕妇更有可能接触到新型病原体。了解传染病损害母胎抗体传递的机制对于大流行病的防备工作非常重要,这样才能最大限度地发挥孕产妇接种疫苗对儿童健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Infections During Pregnancy on Transplacental Antibody Transfer.

Vaccination in pregnancy is important to protect the mother and fetus from infectious diseases. The transfer of maternal antibodies across the placenta during pregnancy can continue to protect the neonate for several months after birth while the neonatal adaptive immune system develops. Several pathogens have been shown to impair the transplacental transfer of maternal antibodies, including human immunodeficiency virus, malaria, the severe acute respiratory syndrome coronavirus 2, and cytomegalovirus. This review discusses the mechanisms contributing to decreased transplacental antibody transfer in the setting of maternal infections, such as changes in antibody glycosylation profile, maternal hypergammaglobulinemia, and placental injury. The frequency of epidemics is increasing, and pregnant people are more likely to become exposed to novel pathogens now than they were in the past. Understanding the mechanisms by which infectious diseases impair maternal-fetal antibody transfer is important for pandemic preparedness to maximize the impact of maternal vaccination for child health.

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来源期刊
Vaccines
Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
8.90
自引率
16.70%
发文量
1853
审稿时长
18.06 days
期刊介绍: Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.
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