抗 PD-1/PD-L1 免疫疗法的新增强剂：PCSK9 抑制剂

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2024-10-24 DOI:10.1016/j.trecan.2024.10.002

Shengbo Sun, Zhengyang Yang, Hongwei Yao, Zhongtao Zhang

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引用次数: 0

摘要

抗程序性细胞死亡蛋白1（PD-1）/PD-1配体1（PD-L1）免疫疗法在癌症治疗中取得了可喜的成果，改善了临床疗效，延长了患者生存期。然而，大多数患者对 PD-1/PD-L1 阻断剂的反应率较低，这凸显了对新增强剂的迫切需求。目前，越来越多的数据表明，抑制丝氨酸蛋白酶--9 型枯草蛋白酶（PCSK9）可以增强抗 PD-1/PD-L1 免疫疗法的抗肿瘤疗效。

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A new enhancer for anti-PD-1/PD-L1 immunotherapy: PCSK9 inhibition.

Anti-programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) immunotherapy has shown promising results in cancer treatment, improving clinical outcomes and prolonging patient survival. However, most patients exhibit low response rates to PD-1/PD-L1 blockade, highlighting the urgent need for new enhancers. Increasing data now demonstrate that inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), a serine proteinase, can enhance the antitumor efficacy of anti-PD-1/PD-L1 immunotherapy.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.