严重的全身性暴力色杆菌感染:法属圭亚那一名德国长期居民的病例研究。

IF 2.8 4区 医学 Q2 INFECTIOUS DISEASES
Caroline Klenk, Miriam Schnieders, Melina Heinemann, Christiane Wiegard, Henning Büttner, Michael Ramharter, Sabine Jordan, Maria Sophia Mackroth
{"title":"严重的全身性暴力色杆菌感染:法属圭亚那一名德国长期居民的病例研究。","authors":"Caroline Klenk, Miriam Schnieders, Melina Heinemann, Christiane Wiegard, Henning Büttner, Michael Ramharter, Sabine Jordan, Maria Sophia Mackroth","doi":"10.3390/tropicalmed9100242","DOIUrl":null,"url":null,"abstract":"<p><p><i>Chromobacterium violaceum</i> is a Gram-negative, facultative anaerobe proteobacterium. Its natural habitat is water and soil in tropical and subtropical regions. Human infections are characterized by rapid dissemination that can lead to high fatality rates. Here, we describe the first case of a <i>C. violaceum</i> infection reported from Germany. A German national with permanent residence in French Guyana contracted a <i>C. violaceum</i> infection presumably while bathing in a barrier lake in Brazil. The patient presented with a high fever and a crusty, erythematous skin lesion at an emergency department in Hamburg, Germany. Ultrasound and a CT scan of the abdomen revealed multiple liver abscesses. <i>C. violaceum</i> was detected in blood and from aspirates of the liver abscesses, using traditional culture methods and modern molecular assays. Prolonged treatment with meropenem and ciprofloxacin led to full recovery. Rapid pathogen detection and treatment initiation are of high importance in <i>C. violaceum</i> infections as mortality rates are overall declining but have still tended to reach up to 25% in recent years in systemic infections. Due to its broad natural drug resistance, antibiotic treatment is challenging. Increased travel activities may lead to more frequent presentation of patients with environmental pathogens of the tropics such as <i>C. violaceum</i>.</p>","PeriodicalId":23330,"journal":{"name":"Tropical Medicine and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511043/pdf/","citationCount":"0","resultStr":"{\"title\":\"Severe Systemic <i>Chromobacterium violaceum</i> Infection: A Case Study of a German Long-Term Resident in French Guyana.\",\"authors\":\"Caroline Klenk, Miriam Schnieders, Melina Heinemann, Christiane Wiegard, Henning Büttner, Michael Ramharter, Sabine Jordan, Maria Sophia Mackroth\",\"doi\":\"10.3390/tropicalmed9100242\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Chromobacterium violaceum</i> is a Gram-negative, facultative anaerobe proteobacterium. Its natural habitat is water and soil in tropical and subtropical regions. Human infections are characterized by rapid dissemination that can lead to high fatality rates. Here, we describe the first case of a <i>C. violaceum</i> infection reported from Germany. A German national with permanent residence in French Guyana contracted a <i>C. violaceum</i> infection presumably while bathing in a barrier lake in Brazil. The patient presented with a high fever and a crusty, erythematous skin lesion at an emergency department in Hamburg, Germany. Ultrasound and a CT scan of the abdomen revealed multiple liver abscesses. <i>C. violaceum</i> was detected in blood and from aspirates of the liver abscesses, using traditional culture methods and modern molecular assays. Prolonged treatment with meropenem and ciprofloxacin led to full recovery. Rapid pathogen detection and treatment initiation are of high importance in <i>C. violaceum</i> infections as mortality rates are overall declining but have still tended to reach up to 25% in recent years in systemic infections. Due to its broad natural drug resistance, antibiotic treatment is challenging. Increased travel activities may lead to more frequent presentation of patients with environmental pathogens of the tropics such as <i>C. violaceum</i>.</p>\",\"PeriodicalId\":23330,\"journal\":{\"name\":\"Tropical Medicine and Infectious Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11511043/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tropical Medicine and Infectious Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3390/tropicalmed9100242\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tropical Medicine and Infectious Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/tropicalmed9100242","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

暴力色杆菌(Chromobacterium violaceum)是一种革兰氏阴性、兼性厌氧变形蛋白杆菌。它的自然栖息地是热带和亚热带地区的水和土壤。人类感染的特点是传播速度快,死亡率高。在此,我们描述了德国报告的首例暴虐杆菌感染病例。一名常住法属圭亚那的德国人可能是在巴西的一个隔离湖中洗澡时感染了暴马蜂疫杆菌。患者在德国汉堡的一家急诊科就诊时出现了高烧和结痂性红斑皮损。腹部超声波和 CT 扫描发现多处肝脓肿。采用传统培养方法和现代分子检测方法,在血液中和肝脓肿的抽吸物中检测出了暴发性大肠杆菌。美罗培南和环丙沙星的长期治疗使患者完全康复。快速检测病原体和开始治疗对暴发性链球菌感染非常重要,因为死亡率总体上在下降,但近年来全身感染的死亡率仍高达 25%。由于其广泛的天然耐药性,抗生素治疗具有挑战性。旅行活动的增加可能会导致热带地区环境病原体(如暴马菌)患者的发病率上升。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Severe Systemic Chromobacterium violaceum Infection: A Case Study of a German Long-Term Resident in French Guyana.

Chromobacterium violaceum is a Gram-negative, facultative anaerobe proteobacterium. Its natural habitat is water and soil in tropical and subtropical regions. Human infections are characterized by rapid dissemination that can lead to high fatality rates. Here, we describe the first case of a C. violaceum infection reported from Germany. A German national with permanent residence in French Guyana contracted a C. violaceum infection presumably while bathing in a barrier lake in Brazil. The patient presented with a high fever and a crusty, erythematous skin lesion at an emergency department in Hamburg, Germany. Ultrasound and a CT scan of the abdomen revealed multiple liver abscesses. C. violaceum was detected in blood and from aspirates of the liver abscesses, using traditional culture methods and modern molecular assays. Prolonged treatment with meropenem and ciprofloxacin led to full recovery. Rapid pathogen detection and treatment initiation are of high importance in C. violaceum infections as mortality rates are overall declining but have still tended to reach up to 25% in recent years in systemic infections. Due to its broad natural drug resistance, antibiotic treatment is challenging. Increased travel activities may lead to more frequent presentation of patients with environmental pathogens of the tropics such as C. violaceum.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease Medicine-Public Health, Environmental and Occupational Health
CiteScore
3.90
自引率
10.30%
发文量
353
审稿时长
11 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信