超越 CRISPR-Cas9 的工业微生物学新兴基因编辑技术。

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-10-26 DOI:10.1016/j.tibtech.2024.09.012

Liya Liang, Huiping Tan, Rongming Liu

引用次数: 0

摘要

CRISPR-Cas9系统已广泛应用于工业微生物学，但对某些微生物无效。本论坛探讨了旨在克服这些挑战的策略，包括使用 Cas12a 系统、Cas9 变体和非 CRISPR 技术，为扩大微生物工程的应用提供更有效的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging gene editing in industrial microbiology beyond CRISPR-Cas9.

The CRISPR-Cas9 system has been widely applied for industrial microbiology but is not effective in certain microorganisms. This forum explores the strategies aimed at overcoming these challenges, including the use of the Cas12a system, Cas9 variants, and non-CRISPR techniques, to provide more effective strategies for expanding applications in microbial engineering.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).