氧化锌纳米颗粒诱导大鼠鼻内灌注后嗅上皮和嗅球的核磁共振成像变化

IF 3.9 3区 环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES
Toxics Pub Date : 2024-10-05 DOI:10.3390/toxics12100724
Lifeng Gao, Yuguang Meng, Xiaowen Luo, Jiangyuan Chen, Xuxia Wang
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引用次数: 0

摘要

自氧化锌(ZnO)纳米粒子(NPs)被广泛应用以来,纳米界和公众对其毒性给予了高度关注。我们利用无创实时磁共振成像(MRI)技术检测了鼻腔暴露 20 纳米氧化锌纳米粒子后的生物毒性。大鼠嗅上皮(OE)和嗅球(OB)在接受治疗后(最早1天,最长21天)在4.7 T扫描仪上扫描了磁共振图像,并对组织学变化进行了评估。研究还探讨了氧化锌纳米粒子的尺寸和化学成分的影响。研究结果表明,在急性期,20 nm ZnO NPs 会引起 OE 和 OB 明显的结构破坏和炎症。研究结果表明,核磁共振成像具有实时性和非侵入性的优势,可以直接、动态地观察和评估长期暴露于氧化锌氮氧化物对嗅觉系统的潜在毒性。这些研究结果表明,氧化锌纳米粒子对嗅球的毒性与尺寸有关。要揭示氧化锌纳米粒子毒性背后的机制,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ZnO Nanoparticles-Induced MRI Alterations to the Rat Olfactory Epithelium and Olfactory Bulb after Intranasal Instillation.

Since zinc oxide (ZnO) nanoparticles (NPs) have been widely applied, the nano community and the general public have paid great attention to the toxicity of ZnO NPs. We detected 20-nm ZnO NPs biotoxicity following nasal exposure utilizing the non-invasive and real-time magnetic resonance imaging (MRI) technique. MR images were scanned in the rat olfactory epithelium (OE) and olfactory bulb (OB) on a 4.7 T scanner following the treatment (as early as 1 day and up to 21 days after), and the histological changes were evaluated. The influence of the size of the ZnO NPs and chemical components was also investigated. Our study revealed that 20-nm ZnO NPs induced obvious structural disruption and inflammation in the OE and OB at the acute stage. The results suggest that the real-time and non-invasive advantages of MRI allow it to observe and assess, directly and dynamically, the potential toxicity of long-term exposure to ZnO NPs in the olfactory system. These findings indicate the size-dependent toxicity of ZnO NPs with respect to the olfactory bulb. Further study is needed to reveal the mechanism behind ZnO NPs' toxicity.

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来源期刊
Toxics
Toxics Chemical Engineering-Chemical Health and Safety
CiteScore
4.50
自引率
10.90%
发文量
681
审稿时长
6 weeks
期刊介绍: The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.
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