2,2',4,4'-四溴二苯醚（BDE-47）对海洋生物的毒理效应和机制。

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2024-10-15 DOI:10.3390/toxics12100747

Boyang Li, Yun Shao, Chen Liu, Jie Wang, Yanzhong Zhu, Xiaoqian Li

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引用次数: 0

摘要

2,2',4,4'-四溴二苯醚（BDE-47）是一种广泛使用的溴化阻燃剂，属于持久性有机污染物（POPs）。BDE-47 释放到海洋环境中后，可通过生物累积、生物放大和代际传播对海洋生物造成一系列毒性影响。这些效应包括致死、运动能力受损、光合毒性、免疫损伤、肝脏毒性、发育障碍和生殖毒性。本文回顾了有关上述 BDE-47 毒性效应和分子机制的最新研究进展。其毒性的主要机制包括氧化应激、DNA 损伤、细胞凋亡、新陈代谢受损和激活 MAPK 信号级联。

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Toxicological Effects and Mechanisms of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) on Marine Organisms.

2,2',4,4'-tetrabromodiphenyl ether (BDE-47) is a widely used brominated flame retardant belonging to persistent organic pollutants (POPs). After being released into the marine environment, BDE-47 can cause a range of toxic effects on marine organisms through bioaccumulation, biomagnification, and intergenerational transmission. These effects include lethality, impaired motility, photosynthetic toxicity, immune damage, liver toxicity, developmental impairments, and reproductive toxicity. This article reviews the latest research progress on the toxic effects and molecular mechanisms of BDE-47 mentioned above. The primary mechanisms underlying its toxicity include oxidative stress, DNA damage, cellular apoptosis, impaired metabolism, and activation of the MAPK signaling cascade.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： The Journal accepts papers describing work that furthers our understanding of the exposure, effects, and risks of chemicals and materials in humans and the natural environment as well as approaches to assess and/or manage the toxicological and ecotoxicological risks of chemicals and materials. The journal covers a wide range of toxic substances, including metals, pesticides, pharmaceuticals, biocides, nanomaterials, and polymers such as micro- and mesoplastics. Toxics accepts papers covering: The occurrence, transport, and fate of chemicals and materials in different systems (e.g., food, air, water, soil); Exposure of humans and the environment to toxic chemicals and materials as well as modelling and experimental approaches for characterizing the exposure in, e.g., water, air, soil, food, and consumer products; Uptake, metabolism, and effects of chemicals and materials in a wide range of systems including in-vitro toxicological assays, aquatic and terrestrial organisms and ecosystems, model mammalian systems, and humans; Approaches to assess the risks of chemicals and materials to humans and the environment; Methodologies to eliminate or reduce the exposure of humans and the environment to toxic chemicals and materials.