从一名健康的中国女性供体中建立诱导多能干细胞系（SDCHi011-A）。

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2024-10-19 DOI:10.1016/j.scr.2024.103588

Shuyun Wang , Qian Zeng , Mengmeng Chen , Haiyan Zhang , Xin Lv

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引用次数: 0

摘要

我们利用非整合重编程技术，从一名 40 岁健康中国汉族女性的外周血单核细胞（PBMC）中生成了一个诱导多能干细胞（iPSC）系。建立的 iPSC 细胞系 SDCHi011-A 表达了多能性标记，可在体外分化为三个生殖层的细胞，核型正常。该细胞系是疾病模型和分子发病机制干细胞研究的宝贵对照系资源。

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Establishment of an induced pluripotent stem cell line (SDCHi011-A) from a healthy Chinese female donor

We generated an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of a healthy 40-year-old Chinese Han female, using non-integrated reprogramming technology. The established iPSC line, SDCHi011-A, expressed pluripotency marker and could differentiate into cells of three germ layers in vitro with normal karyotype. This cell line is a valuable resource as a control line for stem cell research of disease models and molecular pathogenesis.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.