从一名健康的中国女性捐献者身上建立诱导多能干细胞系（SDPHi006-A）是一项成就。

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2024-10-20 DOI:10.1016/j.scr.2024.103590

Jing Shao , Chunhong Shao , Guang Yang , Yan Jin

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引用次数: 0

摘要

我们从一名健康女性捐献者身上分离出外周血单核细胞（PBMC），并利用非整合外显子载体成功将其转化为诱导多能干细胞（iPSC）。这些 iPSCs 显示了正常的核型，表达了多能性标记，并显示了在体外分化成三个生殖层的能力，可用于未来的研究工作。

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Establishing an induced pluripotent stem cell line (SDPHi006-A) from a healthy Chinese female donor represents an accomplishment

We isolated peripheral blood mononuclear cells (PBMCs) from a healthy female donor, and successfully converted into induced pluripotent stem cells (iPSCs) by using non-integrating episomal vectors. These iPSCs displayed a normal karyotype, expressed markers of pluripotency, and showed the capacity to differentiate into three germ layers in vitro, which could be utilized for future research endeavors.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.