基孔肯雅病治疗证据图 [Evidence map of chikungunya treatmentsMapa de la evidencia sobre el tratamiento del chikunguña]。

IF 2 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Andressa Silva de Castro, Carlos Henrique Nery Costa, Dorcas Lamounier Costa, Andressa Barros Ibiapina, Chrisllayne Oliveira da Silva, Jaiane Oliveira Costa, Fábio Solon Tajra, Carmen Verônica Mendes Abdala
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引用次数: 0

摘要

目的:根据文献综述,绘制基孔肯雅病治疗方法的现有证据图:根据文献综述,绘制基孔肯雅病治疗方法的现有证据图:2022 年 5 月,利用 PubMed 和虚拟健康图书馆平台对基孔肯雅热进行了文献检索。为了绘制证据图,按照拉丁美洲和加勒比健康科学信息中心(BIREME)推荐的方法,根据干预类型、结果和效果方向(阳性、阴性、潜在阳性或潜在阴性、不确定或无效果),选择并描述了提及基孔肯雅热的研究:共纳入 15 项研究(系统综述、对照临床试验和叙述性综述),其中既有药物干预,也有非药物干预。所有干预措施都侧重于减轻症状;没有研究专门调查了对抗病毒本身的方法。只有一项关于药物干预的研究报告了积极效果,涉及羟氯喹单药治疗和甲氨蝶呤加磺胺吡啶和羟氯喹联合治疗,以减轻和缓解基孔肯雅病后关节炎引起的疼痛。唯一一项报告氯喹对基孔肯雅病后关节痛有负面影响的研究描述了氯喹的使用情况。在非药物干预措施中,经颅直流电刺激、弹力带运动和普拉提法均有积极效果,尤其是在缓解疼痛和改善关节功能方面:尽管综述没有发现任何在发病后直接作用于病毒的治疗方法,但证据图显示,药物和非药物疗法都有可能治疗基孔肯雅病的症状和后遗症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Evidence map of chikungunya treatmentsMapa de la evidencia sobre el tratamiento del chikunguña].

Objective: Based on a review of the literature, to create a map of the available evidence on the treatment methods for chikungunya.

Method: In May 2022, a literature search on chikungunya was conducted using the PubMed and Virtual Health Library platforms. To create the evidence map, studies that mentioned chikungunya fever were selected and characterized based on the type of intervention, outcome, and direction of the effect (positive, negative, potentially positive or potentially negative, inconclusive, or no effect), following the methodology recommended by the Latin American and Caribbean Center on Health Sciences Information (BIREME).

Results: Fifteen studies (systematic reviews, controlled clinical trials, and narrative reviews) with both pharmacological and non-pharmacological interventions were included. All interventions focused on symptom mitigation; no study specifically investigated ways to combat the virus itself. Only one study on pharmacological interventions reported a positive effect, involving monotherapy with hydroxychloroquine and combined therapy with methotrexate plus sulfasalazine and hydroxychloroquine for reducing and relieving pain caused by post-chikungunya arthritis. The only study to report a negative effect described the use of chloroquine for post-chikungunya arthralgia. Among non-pharmacological interventions, positive effects were noted for transcranial direct current stimulation, elastic band exercises, and the Pilates method, particularly for pain relief and improvement of joint function.

Conclusion: Although the review did not identify any treatments that act directly on the virus after the onset of the disease, the evidence map suggests that it is possible to treat the symptoms and sequelae of chikungunya with both pharmacological and non-pharmacological therapies.

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来源期刊
CiteScore
4.10
自引率
3.80%
发文量
222
审稿时长
20 weeks
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