儿童期的忽视与神经预测错误信号的改变和对新奇事物的反应有关。

IF 5.9 2区 医学 Q1 PSYCHIATRY
Joseph Aloi, Kathleen I Crum, Karina S Blair, Ru Zhang, Johannah Bashford-Largo, Sahil Bajaj, Soonjo Hwang, Bruno B Averbeck, Nim Tottenham, Matthew Dobbertin, R James R Blair
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引用次数: 0

摘要

背景:每八名儿童中就有一名经历过早期生活压力(ELS),这会增加患精神病理学的风险。ELS,尤其是忽视,与奖励反应能力下降有关。然而,很少有人研究过这种被破坏的奖赏反应的计算细节--特别是对奖赏预测错误(RPE)的神经反应--这是成功工具学习的关键信号--以及它们对新刺激的增强程度。本研究的目的是调查虐待和忽视与 RPE 神经表征对新刺激和非新刺激的关联:178名参与者(年龄在10-18岁之间,中位数=14.9,标准差=2.38)在接受功能磁共振成像的同时参与了 "新奇 "任务。在这项任务中,参与者要学会选择新奇或非新奇的刺激,以赢得每次试验从 0 美元到 0.3 美元不等的金钱奖励。虐待和忽视程度通过童年创伤问卷进行测量:结果:与受到较低程度忽视的青少年相比,受到较高程度忽视的青少年表现出内侧和外侧额叶皮层的RPE调节血氧水平依赖性反应降低,尤其是在探索新奇刺激时(p < 0.05,经多重比较校正):这些数据扩展了之前的研究,表明忽视(而非虐待)与内侧和外侧额叶皮层神经 RPE 表征的损伤有关。然而,在新奇任务中,忽视与行为障碍之间并无关联,这表明这些神经差异并不一定会转化为新奇任务中的行为差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Childhood neglect is associated with alterations in neural prediction error signaling and the response to novelty.

Background: One in eight children experience early life stress (ELS), which increases risk for psychopathology. ELS, particularly neglect, has been associated with reduced responsivity to reward. However, little work has investigated the computational specifics of this disrupted reward response - particularly with respect to the neural response to Reward Prediction Errors (RPE) - a critical signal for successful instrumental learning - and the extent to which they are augmented to novel stimuli. The goal of the current study was to investigate the associations of abuse and neglect, and neural representation of RPE to novel and non-novel stimuli.

Methods: One hundred and seventy-eight participants (aged 10-18, M = 14.9, s.d. = 2.38) engaged in the Novelty task while undergoing functional magnetic resonance imaging. In this task, participants learn to choose novel or non-novel stimuli to win monetary rewards varying from $0 to $0.30 per trial. Levels of abuse and neglect were measured using the Childhood Trauma Questionnaire.

Results: Adolescents exposed to high levels of neglect showed reduced RPE-modulated blood oxygenation level dependent response within medial and lateral frontal cortices particularly when exploring novel stimuli (p < 0.05, corrected for multiple comparisons) relative to adolescents exposed to lower levels of neglect.

Conclusions: These data expand on previous work by indicating that neglect, but not abuse, is associated with impairments in neural RPE representation within medial and lateral frontal cortices. However, there was no association between neglect and behavioral impairments on the Novelty task, suggesting that these neural differences do not necessarily translate into behavioral differences within the context of the Novelty task.

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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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