[转移性乳腺癌患者接受sacituzmab govitecan治疗后的长期生存率]

Q3 Medicine

Recenti progressi in medicina Pub Date : 2024-10-01 DOI:10.1701/4357.43484

Carlo Mulas, Luigi Mascia

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引用次数: 0

摘要

本临床病例指的是一名患有转移性乳腺癌的妇女，她曾接受过萨库珠单抗-戈维替康（SG）治疗，并获得了较长的无进展生存期。该病例的特点是肿瘤疾病具有极强的侵袭性，在激素辅助治疗期间复发，转移性疾病呈现出不同于原发肿瘤的免疫组化特征。经过纳帕紫杉醇和阿特珠单抗的一线治疗，以及卡铂和吉西他滨的二线治疗后，二者的生存期都很短，而使用 SG 的三线治疗的特点是获得了完全应答，延长了生存期，并且在治疗 15 个月后的今天仍具有极高的耐受性。

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[Long term survival in patient with metastatic breast cancer treated with sacituzmab govitecan.]

The clinical case presented refers to a woman suffering from metastatic breast cancer treated with sacituzumab govitecan (SG) who has a long progression-free survival. The case is characterized by the extreme aggressiveness of the neoplastic disease that relapses during adjuvant hormonal treatment with a metastatic disease that presents immunohistochemical characteristics different from the primary tumor. After first-line therapy with nabpaclitaxel and atezolizumab and the subsequent one with carboplatin and gemcitabine, both characterized by short PFS, the third line with SG is characterized by obtaining a complete response and a prolonged PFS as well as extreme tolerability that continues to this day after 15 months of treatment.

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来源期刊

Recenti progressi in medicina Medicine-Medicine (all)

CiteScore

0.90

自引率

0.00%

发文量

143

期刊介绍： Giunta ormai al sessantesimo anno, Recenti Progressi in Medicina continua a costituire un sicuro punto di riferimento ed uno strumento di lavoro fondamentale per l"ampliamento dell"orizzonte culturale del medico italiano. Recenti Progressi in Medicina è una rivista di medicina interna. Ciò significa il recupero di un"ottica globale e integrata, idonea ad evitare sia i particolarismi della informazione specialistica sia la frammentazione di quella generalista.