{"title":"应对副作用：乳腺癌女性辅助内分泌治疗的每日日记研究》。","authors":"W Bierbauer, U Scholz, U Güth, C Tausch, C Elfgen","doi":"10.1002/pon.70006","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Adjuvant endocrine therapy (AET) is increasingly being prescribed for up to 10 years to people diagnosed with hormone receptor-positive breast cancer. AET intake is often accompanied by side effects that significantly impact the well-being of people. The way individuals cope with medication-related side effects might play a pivotal role in their emotional adaption.</p><p><strong>Methods: </strong>This intensive-longitudinal study investigated the association between self-reported coping strategies (Brief COPE) and psychological well-being (Patient Health Questionnaire-4) among women undergoing AET. A multilevel factor analysis resulted in the identification of four coping factors, namely, problem-focused, support-focused, meaning-focused, and avoidance-focused coping. Daily coping efforts and experienced side effects were analyzed as predictors of psychological well-being using multilevel modeling.</p><p><strong>Results: </strong>A total of 215 women (M<sub>age</sub> = 56.5 ± 10.9 years) participated, resulting in a total of n = 2080 daily surveys (M = 9.67 ± 1.08). On average, women reported 3.7 ± 2.2 different side effects per day. Days characterized by an elevated frequency of side effects and increased burden were associated with diminished well-being. Using more problem- and meaning-focused strategies than usual to cope with side effects correlated positively with well-being. Conversely, employing more support- and avoidance-focused coping strategies than usual was linked to reduced psychological well-being. Exploratory analyses focusing on individual coping strategies provided nuanced insights into coping behaviors.</p><p><strong>Conclusion: </strong>The present findings underscore the relationship between women's coping efforts concerning medication-related side effects during AET and their daily well-being. Psychosocial education (e.g., cognitive behavioral therapy) may offer valuable benefits for patients by helping them develop adaptive coping strategies to manage side effects.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Coping With Side Effects: A Daily Diary Study in Women With Breast Cancer Living With Adjuvant Endocrine Therapy.\",\"authors\":\"W Bierbauer, U Scholz, U Güth, C Tausch, C Elfgen\",\"doi\":\"10.1002/pon.70006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Adjuvant endocrine therapy (AET) is increasingly being prescribed for up to 10 years to people diagnosed with hormone receptor-positive breast cancer. 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On average, women reported 3.7 ± 2.2 different side effects per day. Days characterized by an elevated frequency of side effects and increased burden were associated with diminished well-being. Using more problem- and meaning-focused strategies than usual to cope with side effects correlated positively with well-being. Conversely, employing more support- and avoidance-focused coping strategies than usual was linked to reduced psychological well-being. Exploratory analyses focusing on individual coping strategies provided nuanced insights into coping behaviors.</p><p><strong>Conclusion: </strong>The present findings underscore the relationship between women's coping efforts concerning medication-related side effects during AET and their daily well-being. 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引用次数: 0
摘要
目的：越来越多被诊断为激素受体阳性乳腺癌的患者开始接受长达 10 年的辅助内分泌治疗（AET）。在接受 AET 治疗的同时，往往会产生副作用，严重影响患者的身心健康。个人应对药物相关副作用的方式可能对其情绪适应性起着关键作用：这项深入的纵向研究调查了接受 AET 治疗的妇女自我报告的应对策略（Brief COPE）与心理健康（患者健康问卷-4）之间的关联。通过多层次因素分析，确定了四个应对因素，即以问题为中心的应对、以支持为中心的应对、以意义为中心的应对和以逃避为中心的应对。使用多层次模型分析了日常应对努力和所经历的副作用对心理健康的预测作用：共有 215 名女性（年龄 = 56.5 ± 10.9 岁）参加了调查，共进行了 n = 2080 次日常调查（M = 9.67 ± 1.08）。妇女平均每天报告 3.7 ± 2.2 种不同的副作用。副作用频率增加和负担加重与幸福感降低有关。在应对副作用时，比平时使用更多注重问题和意义的策略与幸福感呈正相关。相反，比平时采用更多的以支持和回避为重点的应对策略则与心理幸福感降低有关。以个体应对策略为重点的探索性分析为应对行为提供了细致入微的见解：本研究结果强调了妇女在 AET 期间应对药物相关副作用的努力与其日常幸福感之间的关系。社会心理教育（如认知行为疗法）可帮助患者制定适应性应对策略以控制副作用，从而为患者带来宝贵的益处。
Coping With Side Effects: A Daily Diary Study in Women With Breast Cancer Living With Adjuvant Endocrine Therapy.
Objective: Adjuvant endocrine therapy (AET) is increasingly being prescribed for up to 10 years to people diagnosed with hormone receptor-positive breast cancer. AET intake is often accompanied by side effects that significantly impact the well-being of people. The way individuals cope with medication-related side effects might play a pivotal role in their emotional adaption.
Methods: This intensive-longitudinal study investigated the association between self-reported coping strategies (Brief COPE) and psychological well-being (Patient Health Questionnaire-4) among women undergoing AET. A multilevel factor analysis resulted in the identification of four coping factors, namely, problem-focused, support-focused, meaning-focused, and avoidance-focused coping. Daily coping efforts and experienced side effects were analyzed as predictors of psychological well-being using multilevel modeling.
Results: A total of 215 women (Mage = 56.5 ± 10.9 years) participated, resulting in a total of n = 2080 daily surveys (M = 9.67 ± 1.08). On average, women reported 3.7 ± 2.2 different side effects per day. Days characterized by an elevated frequency of side effects and increased burden were associated with diminished well-being. Using more problem- and meaning-focused strategies than usual to cope with side effects correlated positively with well-being. Conversely, employing more support- and avoidance-focused coping strategies than usual was linked to reduced psychological well-being. Exploratory analyses focusing on individual coping strategies provided nuanced insights into coping behaviors.
Conclusion: The present findings underscore the relationship between women's coping efforts concerning medication-related side effects during AET and their daily well-being. Psychosocial education (e.g., cognitive behavioral therapy) may offer valuable benefits for patients by helping them develop adaptive coping strategies to manage side effects.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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