苦瓜对血脂的影响:随机对照试验的系统回顾和元分析》。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Mohammad Reza Amini, Niloufar Rasaei, Moharam Jalalzadeh, Sanaz Pourreza, Azita Hekmatdoost
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引用次数: 0

摘要

研究表明,苦瓜可用于治疗血脂异常。不过,有关研究结果仍存在分歧。本系统研究旨在阐明食用苦瓜对血脂的影响。从开始到 2023 年 2 月 9 日,对 Web of Science、Cochrane Library、PubMed 和 Scopus 等数据库进行了查询。研究评估了甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。效应大小采用加权平均差 (WMD) 和 95% 置信区间 (CI) 计算。八项随机对照试验(RCT)共纳入 423 名参与者。食用苦瓜可显著降低血浆中总胆固醇(WMD;-9.71 mg/dL;CI:-17.69 至-1.74,p = 0.01)和总胆固醇(WMD;-10.24 mg/dL;CI:-19.92 至-0.56,p = 0.03)的浓度。03),而苦瓜并未显著降低血液中的低密度脂蛋白胆固醇(WMD;-8.66 mg/dL;CI:-19.83 至 2.50,p = 0.12)和高密度脂蛋白胆固醇浓度(WMD;0.54 mg/dL;CI:-2.38 至 3.45,p = 0.71)。亚组分析表明,在剂量≤ 2000 毫克/天和干预期≤ 8 周的情况下,总胆固醇和低密度脂蛋白胆固醇显著下降,高密度脂蛋白胆固醇显著上升。此外,对糖尿病患者和糖尿病前期患者的低密度脂蛋白胆固醇和高密度脂蛋白胆固醇影响最大。补充苦瓜会对 TC 和 TG 水平产生积极影响。这项研究的局限性在于短期试验(少于 3 个月)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Bitter Melon (Mormordica charantia) on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Research indicates that bitter melon could be useful in the management of dyslipidemia. Still, there is disagreement concerning the findings. This systematic study was undertaken to clarify the impact of consuming bitter melon on lipid profile. The databases Web of Science, Cochrane Library, PubMed, and Scopus were queried from inception until February 9, 2023. The study assessed triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels. The effect sizes were calculated using weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight randomized controlled trials (RCTs) with a total of 423 participants were included. Bitter melon consumption resulted in a significant decrease in plasma concentrations of TC (WMD; -9.71 mg/dL; CI: -17.69 to -1.74, p = 0.01) and TG (WMD; -10.24 mg/dL; CI: -19.92 to -0.56, p = 0.03), while bitter melon did not significantly lower blood LDL-C (WMD; -8.66 mg/dL; CI: -19.83 to 2.50, p = 0.12) and HDL-C concentrations (WMD; 0.54 mg/dL; CI: -2.38 to 3.45, p = 0.71). Subgroup analysis showed a significant decrease in TC and LDL-C and an increase in HDL-C at a dose of ≤ 2000 mg/day and an intervention period of ≤ 8 weeks. Also, the greatest impact of LDL-C and HDL-C was seen in diabetic and prediabetic people. Bitter melon supplementation positively impacts TC and TG levels. The limitations of this study were short-term trials (less than 3 months).

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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