鼻腔疫苗接种中的甘露糖和乳糖酸:通过 C-Type Lectin 受体增强抗原递送。

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Mariana Colaço, Maria T Cruz, Luís Pereira de Almeida, Olga Borges
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引用次数: 0

摘要

背景/目的:鼻腔疫苗可刺激分泌型 IgA 的分泌,从而增强粘膜免疫反应并预防粘膜部位的疾病,而分泌型 IgA 对病原体的早期中和至关重要。然而,设计有效的鼻腔疫苗具有挑战性,因为鼻腔粘膜具有复杂的免疫机制,必须在保护和耐受持续暴露于吸入病原体之间取得平衡。鼻腔途径还存在独特的配方和递送障碍,例如粘膜层阻碍了抗原的渗透和免疫细胞的进入:方法:本综述重点介绍加强鼻腔疫苗递送的前沿方法,尤其是针对甘露糖受体和巨噬细胞半乳糖型凝集素(MGL)受体等 C 型凝集素受体(CLR)的方法。该研究阐明了这些受体在抗原识别和抗原呈递细胞(APC)吸收抗原中的作用,为优化疫苗递送提供了见解:结果:虽然全面研究靶向糖结合疫苗的开发不属于本研究的范围,但我们提供了基于糖的配体的关键实例,例如乳糖酸和甘露糖,它们可以选择性地靶向鼻粘膜中的CLRs:随着新型病毒感染的增多,本综述旨在促进创新疫苗的设计,并为研究人员、临床医生和疫苗开发人员提供增强呼吸道病原体免疫防御能力的知识,最终保护公众健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mannose and Lactobionic Acid in Nasal Vaccination: Enhancing Antigen Delivery via C-Type Lectin Receptors.

Background/objectives: Nasal vaccines are a promising strategy for enhancing mucosal immune responses and preventing diseases at mucosal sites by stimulating the secretion of secretory IgA, which is crucial for early pathogen neutralization. However, designing effective nasal vaccines is challenging due to the complex immunological mechanisms in the nasal mucosa, which must balance protection and tolerance against constant exposure to inhaled pathogens. The nasal route also presents unique formulation and delivery hurdles, such as the mucous layer hindering antigen penetration and immune cell access.

Methods: This review focuses on cutting-edge approaches to enhance nasal vaccine delivery, particularly those targeting C-type lectin receptors (CLRs) like the mannose receptor and macrophage galactose-type lectin (MGL) receptor. It elucidates the roles of these receptors in antigen recognition and uptake by antigen-presenting cells (APCs), providing insights into optimizing vaccine delivery.

Results: While a comprehensive examination of targeted glycoconjugate vaccine development is outside the scope of this study, we provide key examples of glycan-based ligands, such as lactobionic acid and mannose, which can selectively target CLRs in the nasal mucosa.

Conclusions: With the rise of new viral infections, this review aims to facilitate the design of innovative vaccines and equip researchers, clinicians, and vaccine developers with the knowledge to enhance immune defenses against respiratory pathogens, ultimately protecting public health.

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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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