Manel Fa-Binefa, Albert Clara, Claudia Lamas, Roberto Elosua
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引用次数: 0
摘要
背景：髋部骨折是一个重大的公共卫生问题。了解髋部骨折与饮食和心血管风险之间的流行病学和生物学联系可能对预防髋部骨折具有重要意义：评估地中海饮食（Mediterranean diet，MD）与髋部骨折风险之间的剂量-反应关系：在 PubMed、Scopus 和 Web of Science 数据库中对前瞻性研究进行了系统检索。检索词为 "地中海饮食 "和 "骨折"：从 8 项研究中提取了数据，包括 15 个队列，共纳入 503 174 人。数据分析采用 "非随机干预研究中的偏倚风险"（Risk of Bias in Non-randomized Studies of Interventions）对方法学质量进行评估：数据分析：在 R Studio 软件中使用了 "meta "和 "dosresmeta "软件包。结果表明，高度和中度的MD依从性与髋部骨折风险的降低相关（相对风险[RR] = 0.71 [95% CI, 0.55-0.91]；RR = 0.78[(95% CI, 0.65-0.93]）。这种关联对男性和女性的影响相似。这种关联的剂量-反应模式呈线性关系：坚持服用MD每增加一个点，髋部骨折风险就会降低5.25%：结论：坚持食用 MD 与降低髋部骨折风险有关，呈线性剂量反应模式。这支持推广这种饮食模式以改善骨骼健康：系统综述注册：PROSPERO 注册号CRD42023402284。
Mediterranean Diet and Risk of Hip Fracture: A Systematic Review and Dose-Response Meta-Analysis.
Context: Hip fractures are a major public health concern. Understanding their epidemiologic and biological links with diet and cardiovascular risk may have important implications for prevention.
Objective: To assess the dose-response association of Mediterranean diet (MD) adherence with the risk of hip fracture.
Data sources: A systematic search was conducted in the PubMed, Scopus, and Web of Science databases for prospective studies. Search terms were "Mediterranean Diet" and "Fracture."
Data extraction: Data were extracted from 8 studies, encompassing 15 cohorts that included 503 174 individuals. Methodological quality was assessed using the Risk of Bias in Nonrandomized Studies of Interventions.
Data analysis: The "meta" and "dosresmeta" packages were used in R Studio Software. The results demonstrated that high and moderate MD adherence were associated with a reduced risk of hip fracture (relative risk [RR] = 0.71 [95% CI, 0.55-0.91]; and RR = 0.78[(95% CI, 0.65-0.93], respectively). The effect of the association was similar in men and women. The dose-response pattern of the association was linear: each point increase in MD adherence was associated with a 5.25% reduction in hip fracture risk.
Conclusions: Adherence to MD is associated with a reduction in hip fracture risk, following a linear dose-response pattern. This supports the promotion of this dietary pattern for improving bone health.
期刊介绍：
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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