肾素-血管紧张素-醛固酮系统抑制剂对慢性硬膜下血肿复发的影响:系统回顾和荟萃分析。

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY
Farid Moradi, Benson Joseph, Donya Ebrahimitabar, Hooman Ghasemi, Aida Jarahi, Ehsan Alimohammadi
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引用次数: 0

摘要

本荟萃分析旨在研究肾素-血管紧张素-醛固酮系统(RAAS)抑制剂对慢性硬膜下血肿(cSDH)复发的影响。本研究遵照系统综述和荟萃分析首选报告项目(PRISMA)声明的指导原则,不受时间限制,在PubMed、EMBASE、CINAHL、Web of Science和Cochrane等多个数据库中进行了全面的在线检索。两位审稿人根据预先确定的标准独立筛选标题、摘要和全文,如有任何差异,则与第三位审稿人讨论或协商解决。采用非随机研究方法指数(MINORS)和 Cochrane 的随机对照试验偏倚风险评估工具对纳入研究的质量和偏倚风险进行了评估。在对 6 个数据库进行系统检索后,纳入了 6 项符合研究目标的研究。RAAS 抑制剂组有 404 名参与者,对照组或安慰剂组有 1828 名参与者。使用 Egger 检验对发表偏倚进行的分析表明,各项研究均无偏倚(P = 0.151)。使用 RAAS 抑制剂与不使用 RAAS 抑制剂相比,cSDH 复发的几率比为 OR = 1.06;置信区间为 0.6-1.893,P 值 = 0.818,表明使用 RAAS 抑制剂与 cSDH 复发之间没有显著关联。结果表明,使用 RAAS 抑制剂与 cSDH 复发之间没有明显联系。然而,由于研究的数量和设计有限,而且缺乏临床试验,因此需要进一步研究以确定这种治疗方法的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The impact of renin-angiotensin-aldosterone system inhibitors on the recurrence of chronic subdural hematoma: a systematic review and meta-analysis.

This meta-analysis seeks to investigate the effects of renin-angiotensin-aldosterone system (RAAS) inhibitors on the recurrence of chronic subdural hematoma (cSDH). Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, this study conducted a comprehensive online search across various databases, including PubMed, EMBASE, CINAHL, Web of Science, and Cochrane, without time restrictions. Two reviewers independently screened titles, abstracts, and full texts based on predetermined criteria, resolving any discrepancies through discussion or consultation with a third reviewer. The quality and risk of bias of the included studies were assessed using the Methodological Index for Non-Randomized Studies (MINORS) and Cochrane's tool for evaluating risk of bias in randomized controlled trials. Six studies aligned with the study objectives were included after a systematic search across 6 databases. The RAAS inhibitors group comprised 404 participants, while the control or placebo group included 1828 participants. Analysis for publication bias using the Egger test indicated no bias in the studies (P = 0.151). The odds ratio for cSDH recurrence with RAAS inhibitor use compared to non-use was reported as OR = 1.06; confidence interval 0.6-1.893, p-value = 0.818, showing no significant association between RAAS inhibitor use and cSDH recurrence. The results suggest no significant link between RAAS inhibitor use and cSDH recurrence. However, due to the limited number and design of studies, as well as the lack of clinical trials, further research is needed to determine the effectiveness of this treatment.

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来源期刊
Neurosurgical Review
Neurosurgical Review 医学-临床神经学
CiteScore
5.60
自引率
7.10%
发文量
191
审稿时长
6-12 weeks
期刊介绍: The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.
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