Qingyuan Liu, Zheng Wen, Jun Wu, Yi Yang, Shuo Wang, Zhi Li
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The effect of the interaction between gender and concurrent FD on the cystic formation of VSs was further analyzed.</p><p><strong>Results: </strong>The current study included 1255 patients with VSs (681 females with a median age of 47 years). Of them, 142 (11.3%) were with cystic VSs. A higher percentage of cystic VSs was observed in female patients (P = 0.021), patients with concurrent FDs (P < 0.001) and those with a larger VS volume (P < 0.001). An increasing trend in percentage of cystic VSs was found among patients with from 0 to ≥ 3 FD lesions (P for trend as < 0.001). A multivariate logistic analysis identified concurrent FD (odds ratio, 6.58; 95%CI, 1.66-26.09; P = 0.007) and VS volume (odds ratio, 1.55; 95%CI, 1.66-1.70; P < 0.001) as independent risk factors related to the cystic formation.</p><p><strong>Conclusion: </strong>Concurrent FD is associated with a high incidence of cystic formation in VSs, which provides a new breakthrough point to investigate the underlying mechanism of cystic formation of VSs.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"47 1","pages":"820"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Concurrent fibrous dysplasia is associated with a high incidence of cystic formation in vestibular schwannomas.\",\"authors\":\"Qingyuan Liu, Zheng Wen, Jun Wu, Yi Yang, Shuo Wang, Zhi Li\",\"doi\":\"10.1007/s10143-024-03061-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Fibrous dysplasia (FD) is a rare hereditary bone disorder, typically accompanied by a seemingly-high percentage of cystic changes in central nerve system tumors. 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引用次数: 0
摘要
背景:纤维性发育不良(FD)是一种罕见的遗传性骨病,通常伴有中枢神经系统肿瘤囊变的比例似乎很高。本研究旨在探讨并发 FD 病变与前庭裂隙瘤(VS)囊性形成之间的关联:方法:回顾性纳入我院 2020 年 1 月至 2022 年 9 月期间的 VS 患者。根据造影剂 MRI,VS 被分为囊性和实性两类。根据放射学结果诊断并发 FD。采用逻辑分析法研究并发 FD 与囊性 VS 之间的关系。研究还进一步分析了性别与并发 FD 之间的交互作用对囊性 VS 形成的影响:本次研究共纳入 1255 例 VS 患者(女性 681 例,中位年龄 47 岁)。其中,142 例(11.3%)为囊性 VS。女性患者(P = 0.021)和并发 FD 的患者(P = 0.021)中囊性 VS 的比例较高:并发 FD 与 VS 囊性形成的高发生率有关,这为研究 VS 囊性形成的内在机制提供了一个新的突破点。
Concurrent fibrous dysplasia is associated with a high incidence of cystic formation in vestibular schwannomas.
Background: Fibrous dysplasia (FD) is a rare hereditary bone disorder, typically accompanied by a seemingly-high percentage of cystic changes in central nerve system tumors. This study aimed to investigate the associations between concurrent FD lesions and the cystic formation of vestibular schwannoma (VS).
Methods: Patients with VSs in our institution from January 2020 to September 2022 were retrospectively included. Based on the contrasted MRI, VSs were grouped as the cystic and solid type. Concurrent FD was diagnosed based on the radiological findings. A logistic analysis was applied to investigate the relationship between concurrent FD and cystic VSs. The effect of the interaction between gender and concurrent FD on the cystic formation of VSs was further analyzed.
Results: The current study included 1255 patients with VSs (681 females with a median age of 47 years). Of them, 142 (11.3%) were with cystic VSs. A higher percentage of cystic VSs was observed in female patients (P = 0.021), patients with concurrent FDs (P < 0.001) and those with a larger VS volume (P < 0.001). An increasing trend in percentage of cystic VSs was found among patients with from 0 to ≥ 3 FD lesions (P for trend as < 0.001). A multivariate logistic analysis identified concurrent FD (odds ratio, 6.58; 95%CI, 1.66-26.09; P = 0.007) and VS volume (odds ratio, 1.55; 95%CI, 1.66-1.70; P < 0.001) as independent risk factors related to the cystic formation.
Conclusion: Concurrent FD is associated with a high incidence of cystic formation in VSs, which provides a new breakthrough point to investigate the underlying mechanism of cystic formation of VSs.
期刊介绍:
The goal of Neurosurgical Review is to provide a forum for comprehensive reviews on current issues in neurosurgery. Each issue contains up to three reviews, reflecting all important aspects of one topic (a disease or a surgical approach). Comments by a panel of experts within the same issue complete the topic. By providing comprehensive coverage of one topic per issue, Neurosurgical Review combines the topicality of professional journals with the indepth treatment of a monograph. Original papers of high quality are also welcome.