{"title":"嵌入金纳米粒子的硫醇官能化 Ti3C2Tx MXene 用于环丙沙星的灵敏电化学传感。","authors":"Mari Elancheziyan, Manisha Singh, Keehoon Won","doi":"10.3390/nano14201655","DOIUrl":null,"url":null,"abstract":"<p><p>The unregulated use of ciprofloxacin (CIPF) has led to increased resistance in patients and has threatened human health with issues such as digestive disorders, kidney disorders, and liver complications. In order to overcome these concerns, this work introduces a portable electrochemical sensor based on a disposable integrated screen-printed carbon electrode (SPCE) coated with gold nanoparticle-embedded thiol-functionalized Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene (AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene) for simple, rapid, precise, and sensitive quantification of CIPF in milk and water samples. The high surface area and electrical conductivity of AuNPs are maximized thanks to the strong interaction between AuNPs and SH-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene, which can prevent the aggregation of AuNPs and endow larger electroactive areas. Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene was synthesized from Ti<sub>3</sub>AlC<sub>2</sub> MAX phases, and its thiol functionalization was achieved using 3-mercaptopropyl trimethoxysilane. The prepared AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanocomposite was characterized using FESEM, EDS, XRD, XPS, FTIR, and UV-visible spectroscopy. The electrochemical behavior of the nanocomposite was examined using CV, EIS, DPV, and LSV. The AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/SPCE showed higher electrochemical performances towards CIPF oxidation than a conventional AuNPs-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/SPCE. Under the optimized DPV and LSV conditions, the developed nonenzymatic CIPF sensor displayed a wide range of detection concentrations from 0.50 to 143 μM (DPV) and from 0.99 to 206 μM (LSV) with low detection limits of 0.124 μM (DPV) and 0.171 μM (LSV), and high sensitivities of 0.0863 μA/μM (DPV) and 0.2182 μA/μM (LSV).</p>","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510598/pdf/","citationCount":"0","resultStr":"{\"title\":\"Gold Nanoparticle-Embedded Thiol-Functionalized Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene for Sensitive Electrochemical Sensing of Ciprofloxacin.\",\"authors\":\"Mari Elancheziyan, Manisha Singh, Keehoon Won\",\"doi\":\"10.3390/nano14201655\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The unregulated use of ciprofloxacin (CIPF) has led to increased resistance in patients and has threatened human health with issues such as digestive disorders, kidney disorders, and liver complications. In order to overcome these concerns, this work introduces a portable electrochemical sensor based on a disposable integrated screen-printed carbon electrode (SPCE) coated with gold nanoparticle-embedded thiol-functionalized Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene (AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene) for simple, rapid, precise, and sensitive quantification of CIPF in milk and water samples. The high surface area and electrical conductivity of AuNPs are maximized thanks to the strong interaction between AuNPs and SH-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene, which can prevent the aggregation of AuNPs and endow larger electroactive areas. Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene was synthesized from Ti<sub>3</sub>AlC<sub>2</sub> MAX phases, and its thiol functionalization was achieved using 3-mercaptopropyl trimethoxysilane. The prepared AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene nanocomposite was characterized using FESEM, EDS, XRD, XPS, FTIR, and UV-visible spectroscopy. The electrochemical behavior of the nanocomposite was examined using CV, EIS, DPV, and LSV. The AuNPs-S-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/SPCE showed higher electrochemical performances towards CIPF oxidation than a conventional AuNPs-Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene/SPCE. Under the optimized DPV and LSV conditions, the developed nonenzymatic CIPF sensor displayed a wide range of detection concentrations from 0.50 to 143 μM (DPV) and from 0.99 to 206 μM (LSV) with low detection limits of 0.124 μM (DPV) and 0.171 μM (LSV), and high sensitivities of 0.0863 μA/μM (DPV) and 0.2182 μA/μM (LSV).</p>\",\"PeriodicalId\":18966,\"journal\":{\"name\":\"Nanomaterials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-10-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510598/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanomaterials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.3390/nano14201655\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomaterials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.3390/nano14201655","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Gold Nanoparticle-Embedded Thiol-Functionalized Ti3C2Tx MXene for Sensitive Electrochemical Sensing of Ciprofloxacin.
The unregulated use of ciprofloxacin (CIPF) has led to increased resistance in patients and has threatened human health with issues such as digestive disorders, kidney disorders, and liver complications. In order to overcome these concerns, this work introduces a portable electrochemical sensor based on a disposable integrated screen-printed carbon electrode (SPCE) coated with gold nanoparticle-embedded thiol-functionalized Ti3C2Tx MXene (AuNPs-S-Ti3C2Tx MXene) for simple, rapid, precise, and sensitive quantification of CIPF in milk and water samples. The high surface area and electrical conductivity of AuNPs are maximized thanks to the strong interaction between AuNPs and SH-Ti3C2Tx MXene, which can prevent the aggregation of AuNPs and endow larger electroactive areas. Ti3C2Tx MXene was synthesized from Ti3AlC2 MAX phases, and its thiol functionalization was achieved using 3-mercaptopropyl trimethoxysilane. The prepared AuNPs-S-Ti3C2Tx MXene nanocomposite was characterized using FESEM, EDS, XRD, XPS, FTIR, and UV-visible spectroscopy. The electrochemical behavior of the nanocomposite was examined using CV, EIS, DPV, and LSV. The AuNPs-S-Ti3C2Tx MXene/SPCE showed higher electrochemical performances towards CIPF oxidation than a conventional AuNPs-Ti3C2Tx MXene/SPCE. Under the optimized DPV and LSV conditions, the developed nonenzymatic CIPF sensor displayed a wide range of detection concentrations from 0.50 to 143 μM (DPV) and from 0.99 to 206 μM (LSV) with low detection limits of 0.124 μM (DPV) and 0.171 μM (LSV), and high sensitivities of 0.0863 μA/μM (DPV) and 0.2182 μA/μM (LSV).
期刊介绍：
Nanomaterials (ISSN 2076-4991) is an international and interdisciplinary scholarly open access journal. It publishes reviews, regular research papers, communications, and short notes that are relevant to any field of study that involves nanomaterials, with respect to their science and application. Thus, theoretical and experimental articles will be accepted, along with articles that deal with the synthesis and use of nanomaterials. Articles that synthesize information from multiple fields, and which place discoveries within a broader context, will be preferred. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental or methodical details, or both, must be provided for research articles. Computed data or files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Nanomaterials is dedicated to a high scientific standard. All manuscripts undergo a rigorous reviewing process and decisions are based on the recommendations of independent reviewers.
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